Document Detail

The effects of CT1341, thiopentone and induction- delivery time on the blood gas and acid-base status of lambs delivered by casesarean operation and on the onset of respiration.
MedLine Citation:
PMID:  588179     Owner:  NLM     Status:  MEDLINE    
Caesarean sections were performed on 18 Romney ewes on day 144 of pregnancy. Anaesthesia was induced in 9 ewes with CT 1341 and in 9 ewes with thiopentone and maintained in both groups with halothane administered with oxygen. Surgery was performed with the ewes in lateral recumbency, with respiration unassisted. Blood samples were collected from the intact umbilical artery at the time of delivery and analysed for PO2, PCO2, pH (base deficit was derived). The intervals between ewe induction and lamb delivery (lD), delivery and the onset of breathing (TSR), and delivery and the lamb standing were recorded. Lambs in the CT 1341 group both breathed and stood sooner than lambs in the thiopentone group. Significant linear relationships were only found in the CT 1341 group between TSR interval and PCO2 and pH. No significant correlations were found between the lD interval and any of the biochemical characteristics. The results of this study suggest that lateral recumbency does not interfere with uteroplacental circulation, that CT 1341 (2.2 mg/kg) is associated with less neonatal depression than thiopentone (10 mg/kg) and that severe neonatal hypercarbia may delay the onset of respiration in lambs with minimal drug depression.
M D Copland
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Australian veterinary journal     Volume:  53     ISSN:  0005-0423     ISO Abbreviation:  Aust. Vet. J.     Publication Date:  1977 Sep 
Date Detail:
Created Date:  1978-01-27     Completed Date:  1978-01-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370616     Medline TA:  Aust Vet J     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  436-9     Citation Subset:  IM    
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MeSH Terms
Acid-Base Equilibrium / drug effects*
Alfaxalone Alfadolone Mixture / pharmacology
Anesthesia, General / veterinary*
Anesthesia, Obstetrical / veterinary*
Animals, Newborn / blood,  physiology*
Carbon Dioxide / blood
Cesarean Section / veterinary*
Oxygen / blood
Respiration / drug effects*
Sheep / blood,  physiology*
Thiopental / pharmacology
Time Factors
Reg. No./Substance:
124-38-9/Carbon Dioxide; 76-75-5/Thiopental; 7782-44-7/Oxygen; 8067-82-1/Alfaxalone Alfadolone Mixture

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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