Document Detail


The effects of 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) on food intake in non-deprived C57BL6 mice.
MedLine Citation:
PMID:  17300778     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of the 5HT1A agonist 8-hydroxy-2-(di-n-propylamino)-tetralin (8-OH-DPAT) were investigated on food intake in non-deprived mice. 8-OH-DPAT (50-200 mg/kg) administered subcutaneously (s.c.) 5 min prior to presentation of food, produced a dose-related increase in cumulative food intake in C57BC6 mice. The hyperphagic effect of 8-OH-DPAT (100 mg/kg, s.c.) was abolished by concurrent treatment with the 5HT1A receptor antagonist N-[2-(4-2-methoxyphenyl)-1-piperazinyl]-N-(2-pyridyl) cyclohexanecarboxamide (WAY100635; 0.3 mg/kg, s.c.). These data show that 8-OH-DPAT produces an increase in food consumption in non-deprived mice by a 5-HT1A receptor-mediated mechanism of action.
Authors:
Ivor S Ebenezer; Ashya Surujbally
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-01-19
Journal Detail:
Title:  European journal of pharmacology     Volume:  559     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-03-02     Completed Date:  2007-05-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  184-8     Citation Subset:  IM    
Affiliation:
Neuropharmacology Research Group, School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, PO1 2DT, UK. ivor.ebenezer@port.ac.uk
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MeSH Terms
Descriptor/Qualifier:
8-Hydroxy-2-(di-n-propylamino)tetralin / administration & dosage,  pharmacology*
Animals
Dose-Response Relationship, Drug
Eating / drug effects*
Hyperphagia / metabolism,  physiopathology*
Injections, Subcutaneous
Male
Mice
Mice, Inbred C57BL
Piperazines / pharmacology
Pyridines / pharmacology
Receptor, Serotonin, 5-HT1A / agonists*,  metabolism
Serotonin Agonists / administration & dosage,  pharmacology*
Serotonin Antagonists / pharmacology
Species Specificity
Time Factors
Chemical
Reg. No./Substance:
0/Piperazines; 0/Pyridines; 0/Serotonin Agonists; 0/Serotonin Antagonists; 112692-38-3/Receptor, Serotonin, 5-HT1A; 146714-97-8/WAY 100635; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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