Document Detail


The effects of 8-OH-DPAT and (+/-)-pindolol on isolation-induced ultrasonic vocalizations in 3-, 10-, and 14-day-old rats.
MedLine Citation:
PMID:  10086229     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been established that administration of 5-HT1A agonists attenuates the rate of isolation-induced ultrasonic vocalizations (USV) in 10-day-old rat pups. In this study we extended these findings by examining the effects of administration of the serotonergic 1A receptor agonist, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), and mixed 5-HT1A antagonist/beta adrenergic antagonist, (+/-)-pindolol, in 3-, 10-, and 14-day-old rat pups in order to assess the effect of these drugs from a developmental perspective. At all three ages, 8-OH-DPAT significantly reduced the rate of isolation-induced USV. While only the highest dose (1.0 mg/kg) of 8-OH-DPAT administered to the 10- and 14-day-olds significantly reduced the rate of vocalization, both the 0.1- and 1.0-mg/kg doses significantly attenuated the vocalization rate in the 3-day-olds. Pindolol administration did not alter the rate of USV at any age nor did it block the quieting effect that generally occurs when an anesthetized littermate is placed with the isolated pup. We conclude that 8-OH-DPAT is effective as early as 3 days of age in the quieting of isolation-induced USV and that the regional age-dependent development of 5-HT1A receptors and projections are important factors in the observed differential sensitivity to 8-OH-DPAT administration during development.
Authors:
M P Joyce; S E Carden
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental psychobiology     Volume:  34     ISSN:  0012-1630     ISO Abbreviation:  Dev Psychobiol     Publication Date:  1999 Mar 
Date Detail:
Created Date:  1999-06-22     Completed Date:  1999-06-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  109-17     Citation Subset:  IM; S    
Affiliation:
Department of Psychiatry-Developmental Psychobiology, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
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MeSH Terms
Descriptor/Qualifier:
8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology*
Age Factors
Analysis of Variance
Animals
Animals, Newborn
Behavior, Animal / physiology
Body Temperature / drug effects
Dose-Response Relationship, Drug
Female
Male
Pindolol / pharmacology*
Rats
Rats, Wistar
Sensitivity and Specificity
Serotonin Agonists / pharmacology*
Serotonin Antagonists / pharmacology*
Social Isolation*
Statistics, Nonparametric
Ultrasonics
Vocalization, Animal / drug effects*
Grant Support
ID/Acronym/Agency:
5 K21 DA00160/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Serotonin Agonists; 0/Serotonin Antagonists; 13523-86-9/Pindolol; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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