Document Detail

The effects of 50% oxygen on the resolution of pulmonary injury.
MedLine Citation:
PMID:  6774643     Owner:  NLM     Status:  MEDLINE    
We studied the effects in dogs of long-term inhalation of 50% oxygen on an 8-day course of pulmonary injury caused by intravenous oleic acid. After lung injury, the experimental animals were placed in an environmental chamber where the inspired oxygen fraction (FIO2) was maintained at 0.5 (N = 12) or 0.21 (N = 12). Oleic acid caused a marked increase in venous admixture and a decreae in PaO2, which persisted at about the same concentration for 3 days after injury. These variables gradually returned toward preinjury values at 8 days. There was no significant difference in the clinical course, gravimetric lung water measurements, or lung histologic findings between oxygen-treated and air-breathing control animals. We concluded that 50% oxygen does not affect either the extent or resolution of lung injury induced by a sublethal dosage of oleic acid.
F W Cheney; T W Huang; R Gronka
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  122     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1980-11-24     Completed Date:  1980-11-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  373-9     Citation Subset:  AIM; IM    
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MeSH Terms
Carbon Dioxide / blood
DNA / biosynthesis
Lung / pathology
Lung Diseases / chemically induced,  drug therapy*
Oleic Acids
Oxygen / administration & dosage*,  therapeutic use
Pulmonary Atelectasis / chemically induced
Respiratory Distress Syndrome, Adult / therapy
Grant Support
Reg. No./Substance:
0/Oleic Acids; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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