Document Detail


The effects of 5-azacytidine, 12-O-tetradecanoylphorbol 13-acetate and sodium n-butyrate on reactivation of alphaherpesvirus saimiri from explant cultures of latently infected rabbit dorsal root ganglia.
MedLine Citation:
PMID:  2476529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The DNA hypomethylating agent 5-azacytidine greatly increased the reactivation of alphaherpesvirus saimiri-1 (alpha HVS) from latently infected rabbit dorsal root ganglia, although it inhibited the virus yield and plaque formation efficiency of alpha HVS in Vero cells. 12-O-Tetradecanoylphorbol 13-acetate (a protein kinase C activator) and sodium n-butyrate both had a stimulating action on replication in Vero cells but did not affect the release of alpha HVS from latently infected rabbit dorsal root ganglia.
Authors:
S P Mossman; D A Leib; K McCarthy; C A Hart
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of general virology     Volume:  70 ( Pt 9)     ISSN:  0022-1317     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-10-17     Completed Date:  1989-10-17     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  2507-12     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology, University of Liverpool, U.K.
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MeSH Terms
Descriptor/Qualifier:
Animals
Azacitidine / pharmacology*
Butyrates / pharmacology*
Butyric Acid
Butyric Acids / pharmacology*
Ganglia, Spinal / microbiology*
Herpesvirus 2, Saimiriine / drug effects,  growth & development*,  pathogenicity
Rabbits
Tetradecanoylphorbol Acetate / pharmacology*
Virulence
Virus Activation / drug effects*
Chemical
Reg. No./Substance:
0/Butyrates; 0/Butyric Acids; 107-92-6/Butyric Acid; 16561-29-8/Tetradecanoylphorbol Acetate; 320-67-2/Azacitidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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