Document Detail

The effects of 5-HT receptor ligands on ultrasonic calling in mouse pups.
MedLine Citation:
PMID:  1686487     Owner:  NLM     Status:  MEDLINE    
The influence of a range of drugs acting at various 5-HT receptor sites on the ultrasonic calling of mouse pups was assessed. Calling was decreased by the novel anxiolytics buspirone, ipsapirone and gepirone, and by TFMPP, spiperone, ritanserin and GR 38032F. In contrast, 8-OH-DPAT, DOI and quipazine increased the rate of calling. These effects on ultrasonic calling were independent of sedative or thermoregulatory actions of these drugs. Present data provide further support for the view that ultrasonic calling can be used to assess novel compounds for possible anxiolytic or anxiogenic properties.
K Nastiti; D Benton; P F Brain; M Haug
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience and biobehavioral reviews     Volume:  15     ISSN:  0149-7634     ISO Abbreviation:  Neurosci Biobehav Rev     Publication Date:  1991  
Date Detail:
Created Date:  1992-03-31     Completed Date:  1992-03-31     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7806090     Medline TA:  Neurosci Biobehav Rev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  483-7     Citation Subset:  IM    
Biological Sciences, University College of Swansea, UK.
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MeSH Terms
Anti-Anxiety Agents / pharmacology
Body Temperature / drug effects
Hypnotics and Sedatives
Receptors, Serotonin / drug effects*
Serotonin Antagonists / pharmacology
Vocalization, Animal / drug effects*
Reg. No./Substance:
0/Anti-Anxiety Agents; 0/Hypnotics and Sedatives; 0/Receptors, Serotonin; 0/Serotonin Antagonists

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