| The effects of 17beta-estradiol and vitamin E treatments on oxidative stress and antioxidant levels in brain cortex of diabetic ovariectomized rats. | |
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MedLine Citation:
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PMID: 20511130 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated the effects of 17beta-estradiol (E 2 ) and vitamin E on lipid peroxidation and antioxidant levels in brain cortex of diabetic ovariectomized (OVX) rats. Forty-two rats were equally divided into seven groups: Control; OVX; OVX+E 2 ; OVX+E 2 +vitamin E; OVX+diabetic; OVX+diabetic+E 2 and OVX+diabetic+E 2 +vitamin E. Then, E 2 (40 microg kg -1 /day) and vitamin E (100 mg kg -1 /day) were given. Glutathione peroxidase (GSH-Px), catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), vitamin A and beta-carotene in brain were decreased (p<0.05) when compared with control in OVX but MDA in brain and glucose in plasma were elevated (p<0.05). The antioxidant levels in brain (p<0.05) increased although MDA (p<0.05) in brain and glucose (p<0.05, p<0.01) in plasma decreased in OVX after E 2 and E 2 +vitamin E supplementation. The activities of GSH-Px (p<0.001, p<0.01), CAT (p<005, p<0.001) and SOD (p<0.001) and the levels of GSH (p<0.001), vitamin A (p<0.05) and beta-carotene (p<0.001, p<0.05) were lower in the brain of OVX diabetic rats, while MDA in the brain and glucose in the plasma were higher (p<0.001). The antioxidant enzymes (p<0.05, p<0.01), GSH, vitamin A and beta-carotene (p<0.01, p<0.001) in brain increased while MDA in brain and glucose in plasma decreased (p<0.01, p<0.001) in diabetic OVX after treatments. Finally, the E 2 and E 2 +vitamin E supplementation to diabetic OVX and OVX rats may strengthen the antioxidant system by reducing lipid peroxidation. |
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Authors:
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M Ulas; M Cay |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta physiologica Hungarica Volume: 97 ISSN: 0231-424X ISO Abbreviation: Acta Physiol Hung Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-07-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309201 Medline TA: Acta Physiol Hung Country: Hungary |
Other Details:
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Languages: eng Pagination: 208-15 Citation Subset: IM |
Affiliation:
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Department of Physiology, Faculty of Medicine, Firat University, Elazig, Turkey. ulas.mustafa@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antioxidants / administration & dosage*, metabolism Blood Glucose / metabolism Catalase / metabolism Cerebral Cortex / drug effects*, metabolism Diabetes Mellitus, Experimental / drug therapy*, metabolism Estradiol / administration & dosage* Female Glutathione / metabolism Glutathione Peroxidase / metabolism Lipid Peroxidation / drug effects Malondialdehyde / metabolism Ovariectomy* Oxidative Stress / drug effects* Rats Rats, Wistar Superoxide Dismutase / metabolism Vitamin A / metabolism Vitamin E / administration & dosage* beta Carotene / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Blood Glucose; 11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 50-28-2/Estradiol; 542-78-9/Malondialdehyde; 70-18-8/Glutathione; 7235-40-7/beta Carotene; EC 1.11.1.6/Catalase; EC 1.11.1.9/Glutathione Peroxidase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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