| The effects of 17 beta-oestradiol plus dydrogesterone compared with conjugated equine oestrogens plus medroxyprogesterone acetate on lipids, apolipoproteins and lipoprotein(a). | |
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MedLine Citation:
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PMID: 15488354 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To compare the effects of 17 beta-oestradiol plus dydrogesterone with conjugated equine oestrogens plus medroxyprogesterone acetate on serum lipids, apolipoproteins and lipoprotein(a) in postmenopausal women. METHODS: A multi-centre, prospective, randomised, double-blind, comparative one-year study in 362 healthy postmenopausal women aged 39-74 years with an intact uterus. Fasting blood samples were taken at baseline and after 28 and 52 weeks of treatment. Participants received daily oral treatment with continuous combined 1 mg micronised 17 beta-oestradiol/5 mg dydrogesterone (E/D: n=180) or 0.625 mg conjugated equine oestrogens/5 mg medroxyprogesterone acetate (CEE/MPA: n=182). RESULTS: Significant differences between the two groups after 52 weeks were observed for total cholesterol (E/D: -1.7%; CEE/MPA: -7.3%), LDL-cholesterol (E/D: -4.5%; CEE/MPA: -11.3%), HDL-cholesterol (E/D: +15.3%; CEE/MPA: +7.5%), triglycerides (E/D: +9.8%; CEE/MPA: +16.6%), VLDL-triglycerides (E/D: -3.3%; CEE/MPA: +10.0%), lipoprotein(a) (E/D: 0.0%; CEE/MPA: -25.2%) and for the ratio apolipoprotein B/LDL-cholesterol (E/D: +0.9%; CEE/MPA +5.9%). CONCLUSIONS: E/D and CEE/MPA differ in their anti-atherogenic effects on lipids and lipoproteins. This however can not easily be translated to differences in clinical cardiovascular outcomes. |
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Authors:
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Alyde T de Kraker; Peter Kenemans; Raimond G V Smolders; Maurice V A M Kroeks; Marius J van der Mooren |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Maturitas Volume: 49 ISSN: 0378-5122 ISO Abbreviation: Maturitas Publication Date: 2004 Nov |
Date Detail:
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Created Date: 2004-10-18 Completed Date: 2005-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7807333 Medline TA: Maturitas Country: Ireland |
Other Details:
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Languages: eng Pagination: 253-63 Citation Subset: IM |
Affiliation:
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Project Ageing Women, Department of Obstetrics, Diakonessenhuis Utrecht, VU University Medical Center Amsterdam, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Apolipoproteins / blood, drug effects Cardiovascular Diseases / blood, prevention & control* Double-Blind Method Dydrogesterone / administration & dosage Estradiol / administration & dosage Estrogen Replacement Therapy* Estrogens, Conjugated (USP) / administration & dosage Female Great Britain Humans Lipids / blood* Lipoprotein(a) / blood, drug effects Medroxyprogesterone / administration & dosage Middle Aged Netherlands Postmenopause Prospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins; 0/Estrogens, Conjugated (USP); 0/Lipids; 0/Lipoprotein(a); 152-62-5/Dydrogesterone; 50-28-2/Estradiol; 520-85-4/Medroxyprogesterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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