Document Detail

The effects of 10 weeks of resistance training combined with beta-alanine supplementation on whole body strength, force production, muscular endurance and body composition.
MedLine Citation:
PMID:  18175046     Owner:  NLM     Status:  MEDLINE    
Carnosine (Carn) occurs in high concentrations in skeletal muscle is a potent physico-chemical buffer of H+ over the physiological range. Recent research has demonstrated that 6.4 g x day(-1) of beta-alanine (beta-ala) can significantly increase skeletal muscle Carn concentrations (M-[Carn]) whilst the resultant change in buffering capacity has been shown to be paralleled by significant improvements in anaerobic and aerobic measures of exercise performance. Muscle carnosine increase has also been linked to increased work done during resistance training. Prior research has suggested that strength training may also increase M-[Carn] although this is disputed by other studies. The aim of this investigation is to assess the effect of 10 weeks resistance training on M-[Carn], and, secondly, to investigate if increased M-[Carn] brought about through beta-ala supplementation had a positive effect on training responses. Twenty-six Vietnamese sports science students completed the study. The subjects completed a 10-week resistance-training program whilst consuming 6.4 g x day(-1) of beta-ala (beta-ALG) or a matched dose of a placebo (PLG). Subjects were assessed prior to and after training for whole body strength, isokinetic force production, muscular endurance, body composition. beta-Alanine supplemented subjects increased M-[Carn] by 12.81 +/- 7.97 mmol x kg(-1) dry muscle whilst there was no change in PLG subjects. There was no significant effect of beta-ala supplementation on any of the exercise parameters measured, mass or % body fat. In conclusion, 10 weeks of resistance training alone did not change M-[Carn].
Iain P Kendrick; Roger C Harris; Hyo Jeong Kim; Chang Keun Kim; Viet H Dang; Thanh Q Lam; Toai T Bui; Marcus Smith; John A Wise
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Publication Detail:
Type:  Journal Article     Date:  2008-01-04
Journal Detail:
Title:  Amino acids     Volume:  34     ISSN:  1438-2199     ISO Abbreviation:  Amino Acids     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-06     Completed Date:  2008-08-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200312     Medline TA:  Amino Acids     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  547-54     Citation Subset:  IM    
University of Chichester, College Lane, Chichester, West Sussex PO196PE, UK.
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MeSH Terms
Analysis of Variance
Body Composition / drug effects,  physiology
Carnosine / biosynthesis
Dietary Supplements*
Isotonic Contraction / drug effects,  physiology
Muscle Strength / drug effects,  physiology
Muscle, Skeletal / drug effects,  metabolism
Physical Education and Training / methods*
Physical Endurance / drug effects,  physiology
Reference Values
Sensitivity and Specificity
Time Factors
beta-Alanine / administration & dosage*
Reg. No./Substance:
0/Placebos; 107-95-9/beta-Alanine; 305-84-0/Carnosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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