Document Detail


The effectiveness of splenic autotransplantation: an experimental study.
MedLine Citation:
PMID:  17310406     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The purpose of this study was to establish the effects of spleen autotransplantation on immunity and to examine the viability of autotransplanted spleen tissue. METHODS: Three groups were assigned and following operations were performed in twenty New Zealand rabbits. 1st group: sham laparotomy, 2nd group: splenectomy and 3rd group: splenectomy and splenic autotransplantation. Scintigraphic methods, hematological-immunological tests and histopathological examination were used to evaluate the effects of splenic autotransplantation. RESULTS: Histopathological findings showed that eight rabbits had splenic regrowth and two had necrosis of autotransplanted splenic tissue. Preoperative hematological and immunological findings compared with those at sixth week postoperatively. In group 3, postoperative immunoglobulin G, immunoglobulin M and interleukin-1 levels were significantly increased when compared with preoperative levels. Between all groups, postoperative leukocyte counts were found to be significantly higher in group 2 comparing with group 1. In group 2, postoperative platelet counts were significantly higher in comparison to group 1 and 3. No statistically significant difference was detected between the groups for immunoglobulin G, immunoglobulin M and interleukin-1 levels. CONCLUSION: Conservative treatment is important in patients with splenic injury. However when splenectomy is indicated, splenic autotransplantation into the omentum pouch could be a reliable method for reconstruction of splenic functions and the viability of the implanted spleen tissue can be monitored by scintigraphy and laboratory examination.
Authors:
Erdal Karagülle; Zeki Hoşcoşkun; Ali Kemal Kutlu; Meryem Kaya; Serkan Baydar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES     Volume:  13     ISSN:  1306-696X     ISO Abbreviation:  Ulus Travma Acil Cerrahi Derg     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-02-20     Completed Date:  2007-07-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101274231     Medline TA:  Ulus Travma Acil Cerrahi Derg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  13-9     Citation Subset:  IM    
Affiliation:
Department of General Surgery, Medicine Faculty of Başkent University, Ankara, Turkey. erdalk@mail.baskent-kon.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Animals
Female
Immunoglobulin G / blood
Immunoglobulin M / blood
Interleukin-1 / blood
Leukocyte Count
Organ Transplantation
Platelet Count
Rabbits
Radionuclide Imaging
Regeneration / immunology*
Spleen / physiology*,  radionuclide imaging,  transplantation*
Splenectomy
Transplantation, Autologous
Chemical
Reg. No./Substance:
0/Immunoglobulin G; 0/Immunoglobulin M; 0/Interleukin-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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