| The effectiveness of relative dose response to retinol intake as an evaluation of vitamin A status of cirrhotic patients. | |
| | |
MedLine Citation:
|
PMID: 20487170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The liver is the main organ involved in homeostasis, metabolism and the storage of retinol. During the fibrotic process, hepatic stellate cells lose their lipid drops, and retinol reserves may deplete. Thus, the present study aimed to evaluate serum retinol levels (RL), hepatic retinol storage and dietary vitamin A intake in cirrhotic patients. METHODS: RL were measured by high-performance liquid chromatography in fifty-eight cirrhotic patients. Fasting RL <1.05 μmol L⁻¹ indicates vitamin A deficiency (VAD). A relative dose response (RDR) to oral retinol ≥20% indicates an inadequate hepatic retinol reserve (positive test). Severe malnutrition was defined as a mid-arm muscle circumference (MAMC) and/or triceps skinfold thickness (TSF) below the 5th percentile and moderate malnutrition as MAMC and/or TSF below the 10th percentile. Vitamin A daily intake was estimated by a specific questionnaire. The Child-Pugh classification of liver disease severity and the Model for End-Stage Liver Disease were used. RESULTS: Low RL were found in 60% of the patients. Twenty-three cirrhotic patients had adequate fasting RL (RL = 1.34; 1.05-2.12 μmol L⁻¹) and negative RDR, indicating efficient liver stores. Among thirty-five cirrhotic patients with low RL, 43% had negative RDR (RL = 0.42; 0.06-0.82 μmol L⁻¹) and 57% had positive RDR (RL = 0.45; 0.09-0.93 μmol L⁻¹). Malnutrition (36%) and inadequate vitamin A intake (55%) were not associated with fasting RL or RDR. CONCLUSIONS: VAD was highly prevalent in cirrhotic patients. However, in those with low serum RL and negative RDR, factors other than inadequate vitamin A intake, such as impaired hepatic vitamin A mobilization and intestinal vitamin A malabsorption, which were not examined in the present study, could have influenced the negative results obtained by the RDR method. |
| | |
Authors:
|
T P de Paula; A Ramalho; V B Braulio |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of human nutrition and dietetics : the official journal of the British Dietetic Association Volume: 23 ISSN: 1365-277X ISO Abbreviation: J Hum Nutr Diet Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-10-29 Completed Date: 2011-01-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8904840 Medline TA: J Hum Nutr Diet Country: England |
Other Details:
|
Languages: eng Pagination: 583-9 Citation Subset: IM |
Copyright Information:
|
© 2010 The Authors. Journal compilation © 2010 The British Dietetic Association Ltd. |
Affiliation:
|
Division of Metabolism and Nutrition, University Hospital, Federal University of Rio de Janeiro, RJ, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Diet* Dose-Response Relationship, Drug Fasting Female Humans Liver Cirrhosis / blood*, complications Male Malnutrition / complications, diagnosis Middle Aged Nutritional Status* Severity of Illness Index Vitamin A / administration & dosage*, blood*, diagnostic use Vitamin A Deficiency / complications, diagnosis* |
| Chemical | |
Reg. No./Substance:
|
11103-57-4/Vitamin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Body height estimation from head and face dimensions: a different method.
Next Document: Neighbourhood deprivation and the price and availability of fruit and vegetables in Scotland.