Document Detail

The effectiveness of nasal decongestants, oral decongestants and oral decongestant-antihistamines in the treatment of acute otitis media in children.
MedLine Citation:
PMID:  20030596     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this study was to evaluate the effectiveness of nasal decongestants, oral decongestants and oral decongestant-antihistamines in the treatment of acute otitis media and resolution of the middle ear effusion in children. PATIENTS AND METHODS: 355 ears of 318 children [160 boys (179 ears) and 158 girls (176 ears)] who were diagnosed to have acute otitis media and treated for it with different drug regimens were evaluated retrospectively regarding resolution of the middle ear fluid. 151 ears were treated with antibiotics and analgesics (group 1), 64 with antibiotics, topical decongestants and analgesics (group 2), 81 with antibiotics, oral decongestants and analgesics (group 3), and 59 with antibiotics, oral decongestant-antihistamine combinations and analgesics (group 4). The children with middle ear effusion were followed up for three months. RESULTS: Group 1, 2, 3 and 4 had persistent middle ear effusion and the presence of middle ear effusion was 27.2%, 18.8%, 25.9%, 28.8% at the 1st month and 5.8%, 0%, 0% and 5.9% at the end of the 3rd month, respectively. At the end of the 3rd month, there was no significant difference between the groups regarding the resolution rates of the middle ear fluids in the antibiotic group and decongestants groups (p>0.05). CONCLUSION: We do not recommend the use of decongestants and antihistamines in the treatment of acute otitis media as they do not change the natural course of the disease.
Ahmet Eyibilen; Ibrahim Aladağ; Mehmet Güven; Sema Koç; Levent Gürbüzler
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kulak burun boğaz ihtisas dergisi : KBB = Journal of ear, nose, and throat     Volume:  19     ISSN:  1300-7475     ISO Abbreviation:  Kulak Burun Bogaz Ihtis Derg     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-12-24     Completed Date:  2010-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100899230     Medline TA:  Kulak Burun Bogaz Ihtis Derg     Country:  Turkey    
Other Details:
Languages:  eng     Pagination:  289-93     Citation Subset:  IM    
Department of Otolaryngology, Medicine Faculty of Gaziosmanpaşa University, Tokat, Turkey.
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MeSH Terms
Acoustic Impedance Tests
Acute Disease
Administration, Intranasal
Administration, Oral
Analgesics / therapeutic use
Anti-Bacterial Agents / therapeutic use
Child, Preschool
Drug Therapy, Combination
Histamine Antagonists / standards,  therapeutic use*
Nasal Decongestants / standards,  therapeutic use*
Otitis Media with Effusion / drug therapy*
Retrospective Studies
Sex Factors
Treatment Outcome
Reg. No./Substance:
0/Analgesics; 0/Anti-Bacterial Agents; 0/Histamine Antagonists; 0/Nasal Decongestants

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