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The effectiveness of intralesional injection of platelet-rich plasma in accelerating the healing of chronic ulcers. An experimental and clinical study.
MedLine Citation:
PMID:  22672105     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The purpose of this prospective experimental and clinical study is to evaluate the effectiveness of the intralesional injection of platelet-rich plasma (PRP), in the management of non healing chronic wounds. Skin defects were created at the ears of 20 white New Zealand rabbits. In the study group, autologous PRP was injected intralesionally. The control group was treated conservatively. Nineteen out of 20 cases of the study group healed within a mean time of 24·9 days. At the control group, seven defects healed within a mean period of 26·7 days, seven ulcers did not heal at the day 28 and in six cases a full thickness ear defect was recorded. For a 3-year period, 26 patients with chronic ulcers underwent surgical debridement and intralesional injection of PRP. A histological study was performed before and 7 days after PRP injection. Ten patients healed within a mean period of 7 weeks. In 16 cases, PRP prepared the wound bed for the final and simpler reconstructive procedure. Intralesional injection is a newly described method for application of PRP and represents an effective therapeutic option when dealing with non healing wounds.
Authors:
Dimitrios Dionyssiou; Efterpi Demiri; Pericles Foroglou; Aggeliki Cheva; Nikolaos Saratzis; Constantine Aivazidis; George Karkavelas
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-4
Journal Detail:
Title:  International wound journal     Volume:  -     ISSN:  1742-481X     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101230907     Medline TA:  Int Wound J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors. International Wound Journal © 2012 Blackwell Publishing Ltd and Medicalhelplines.com Inc.
Affiliation:
D Dionyssiou, MD, PhD, Department of Plastic Surgery, Aristotle University Thessaloniki, Thessaloniki, Greece E Demiri, MD, PhD, Department of Plastic Surgery, Aristotle University Thessaloniki, Thessaloniki, Greece P Foroglou, MD, PhD, Department of Plastic Surgery, Aristotle University Thessaloniki, Thessaloniki, Greece A Cheva, MD, PhD, Laboratory of Pathology, Aristotle University Thessaloniki, Thessaloniki, Greece N Saratzis, MD, PhD, Department of Surgery and Vascular Surgery, Aristotle University Thessaloniki, Thessaloniki, Greece C Aivazidis, PhD, Quality Assurance Unit, Aristotle University Thessaloniki, Thessaloniki, Greece G Karkavelas, MD, PhD, Laboratory of Pathology, Aristotle University Thessaloniki, Thessaloniki, Greece.
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