Document Detail


The effect of zinc supplements in cystic fibrosis patients.
MedLine Citation:
PMID:  18446019     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To study the effect of Zn supplements in cystic fibrosis (CF) on disease evolution. METHODS: A retrospective study of all CF patients treated with Zn supplements (January 2002 to December 2004). Data from patient files for the year before and the first year of supplementation were compared. The controls were CF patients with normal serum Zn and without Zn supplementation. RESULTS: 21 patients (7 females), median age 8.9 (interquartile range 13.1) years, received 5 mg/kg Zn sulfate/day (maximum 150 mg). The number of infections decreased from 3 (1.25) to 2 (2.0) (tied p < 0.02) and the forced expiratory volume in 1 s (FEV(1)) increased from 72.0 (38.4) to 76.5 (52)% (p < 0.02). Energy intake improved (92.3 (14.5) to 117.0 (28.5)%; tied p < 0.02), as did weight for height (W/H; 90 (9.4) to 94 (8.5)%; tied p = 0.043). In the CF control patients the number of infections (2.0 (2.0)), energy intake (116 (43.3)%) and nutritional status remained stable (W/H 99 (17.2)%), but pulmonary function decreased significantly (DeltaFEV(1) loss of 2.0 (8.0)%). There was a significantly different evolution for the change in forced vital capacity (p < 0.004) and DeltaFEV(1) (p < 0.001) between supplemented and control patients. CONCLUSIONS: Analysis of the clinical data on Zn supplementation in CF showed beneficial effects in Zn-deficient CF patients. These results must be confirmed in a prospective double-blind randomized control trial.
Authors:
S Van Biervliet; S Vande Velde; J P Van Biervliet; E Robberecht
Related Documents :
7544219 - Effect of postoperative insulin-like growth factor i supplementation on protein metabol...
19856209 - Effect of nutritional status and sampling intensity on recovery after dorsal aorta cann...
10369709 - A double blind, randomised, controlled trial of glutamine supplementation in parenteral...
17622869 - Prospective randomized control trial of intermittent versus continuous gastric feeds fo...
24401539 - Is soluble mesothelin-related protein an upfront predictive marker of pleural mesotheli...
3493979 - Treatment of uremic patients with biofiltration: efficacy, biocompatibility and medium-...
19126059 - Efficacy and safety of tarcrolimus cream 0.1% in the treatment of vitiligo.
24340229 - Long-term therapeutic effects of corticoamygdalohippocampectomy for bilateral mesial te...
16999629 - Erectile dysfunction after plasmakinetic vaporization of the prostate: incidence and ri...
Publication Detail:
Type:  Journal Article     Date:  2008-04-29
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  52     ISSN:  1421-9697     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-21     Completed Date:  2008-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  152-6     Citation Subset:  IM    
Copyright Information:
2008 S. Karger AG, Basel.
Affiliation:
Pediatric Department, UZ Ghent, Ghent, Belgium. stephanie.vanbiervliet@ugent.be
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Appetite / drug effects
Child
Child, Preschool
Cohort Studies
Cystic Fibrosis / complications*
Dietary Supplements*
Disease Susceptibility
Energy Intake / drug effects
Exocrine Pancreatic Insufficiency / etiology
Female
Forced Expiratory Volume
Growth Disorders / etiology
Humans
Infection / epidemiology
Intervention Studies
Male
Retrospective Studies
Serum Albumin / analysis
Steatorrhea / etiology*,  metabolism
Thinness / etiology
Vital Capacity
Vitamins / blood
Zinc / blood,  deficiency*,  therapeutic use*
Chemical
Reg. No./Substance:
0/Serum Albumin; 0/Vitamins; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Dose and time effects of estrogen on expression of neuron-specific protein and cyclic AMP response e...
Next Document:  Supplementation with 200 mg/day docosahexaenoic acid from mid-pregnancy through lactation improves t...