Document Detail

The effect of zinc supplements in cystic fibrosis patients.
MedLine Citation:
PMID:  18446019     Owner:  NLM     Status:  MEDLINE    
AIM: To study the effect of Zn supplements in cystic fibrosis (CF) on disease evolution. METHODS: A retrospective study of all CF patients treated with Zn supplements (January 2002 to December 2004). Data from patient files for the year before and the first year of supplementation were compared. The controls were CF patients with normal serum Zn and without Zn supplementation. RESULTS: 21 patients (7 females), median age 8.9 (interquartile range 13.1) years, received 5 mg/kg Zn sulfate/day (maximum 150 mg). The number of infections decreased from 3 (1.25) to 2 (2.0) (tied p < 0.02) and the forced expiratory volume in 1 s (FEV(1)) increased from 72.0 (38.4) to 76.5 (52)% (p < 0.02). Energy intake improved (92.3 (14.5) to 117.0 (28.5)%; tied p < 0.02), as did weight for height (W/H; 90 (9.4) to 94 (8.5)%; tied p = 0.043). In the CF control patients the number of infections (2.0 (2.0)), energy intake (116 (43.3)%) and nutritional status remained stable (W/H 99 (17.2)%), but pulmonary function decreased significantly (DeltaFEV(1) loss of 2.0 (8.0)%). There was a significantly different evolution for the change in forced vital capacity (p < 0.004) and DeltaFEV(1) (p < 0.001) between supplemented and control patients. CONCLUSIONS: Analysis of the clinical data on Zn supplementation in CF showed beneficial effects in Zn-deficient CF patients. These results must be confirmed in a prospective double-blind randomized control trial.
S Van Biervliet; S Vande Velde; J P Van Biervliet; E Robberecht
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Publication Detail:
Type:  Journal Article     Date:  2008-04-29
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  52     ISSN:  1421-9697     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  2008  
Date Detail:
Created Date:  2008-05-21     Completed Date:  2008-09-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  152-6     Citation Subset:  IM    
Copyright Information:
2008 S. Karger AG, Basel.
Pediatric Department, UZ Ghent, Ghent, Belgium.
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MeSH Terms
Appetite / drug effects
Child, Preschool
Cohort Studies
Cystic Fibrosis / complications*
Dietary Supplements*
Disease Susceptibility
Energy Intake / drug effects
Exocrine Pancreatic Insufficiency / etiology
Forced Expiratory Volume
Growth Disorders / etiology
Infection / epidemiology
Intervention Studies
Retrospective Studies
Serum Albumin / analysis
Steatorrhea / etiology*,  metabolism
Thinness / etiology
Vital Capacity
Vitamins / blood
Zinc / blood,  deficiency*,  therapeutic use*
Reg. No./Substance:
0/Serum Albumin; 0/Vitamins; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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