| The effect of yohimbine on the turnover of brain catecholamines and serotonin. | |
| | |
MedLine Citation:
|
PMID: 1175676 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Yohimbine moderately increased the depletion of brain dopamine (DA) after alpha-methyl-p-tyrosine (AMT) only when the two drugs were given at the same time; the baseline concentration of brain homovanillic acid (HVA) and its accumulation after probenecid were strongly increased by yohimbine. Yohimbine markedly decreased the concentration of brain noradrenaline (NA), both when given alone and before or at the same time as AMT; when it was given at an increasing interval after AMT, the effect became progressively smaller. The baseline concentration of brain 3-methyoxy-4-hydroxyphenylethyleneglycol sulphate and its accumulation after probenecid were increased by yohimbine; this effect was not as marked as that on HVA and was proportional to the quantity of NA depleted in the Amt method. The accumulation of brain k-hydroxyindoleacetic acid after probenecid was decreased by yohimbine pretreatment. |
| | |
Authors:
|
R Papeschi; P Theiss |
Related Documents
:
|
2129086 - Pathophysiology of acute brain damage following epilepsy. 11162146 - Analysis of amino acids and catecholamines, 5-hydroxytryptamine and their metabolites i... 211586 - Polarity of the blood-brain barrier: neutral amino acid transport into isolated brain c... 2935746 - The fatty acid composition of glycerolipids in nerve, brain, and other tissues of the s... 21217876 - Toxicity of perfluorinated carboxylic acids for aquatic organisms. 16381666 - Metabolism and excretion of erlotinib, a small molecule inhibitor of epidermal growth f... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of pharmacology Volume: 33 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1975 Aug |
Date Detail:
|
Created Date: 1975-12-20 Completed Date: 1975-12-20 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 1-12 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Brain / drug effects, metabolism* Catecholamines / metabolism* Dopamine / metabolism Homovanillic Acid / metabolism Hydroxyindoleacetic Acid / metabolism Male Methoxyhydroxyphenylglycol / metabolism Methyltyrosines / diagnostic use Norepinephrine / metabolism Probenecid / diagnostic use Rats Serotonin / metabolism* Time Factors Yohimbine / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Catecholamines; 0/Methyltyrosines; 146-48-5/Yohimbine; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid; 57-66-9/Probenecid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synthesis of immunoglobulins and 15 other proteins by diseased human kidneys.
Next Document: Centrally mediated hypotension and bradycardia by methysergide in anesthetized dogs.