Document Detail

The effect of yohimbine on the turnover of brain catecholamines and serotonin.
MedLine Citation:
PMID:  1175676     Owner:  NLM     Status:  MEDLINE    
Yohimbine moderately increased the depletion of brain dopamine (DA) after alpha-methyl-p-tyrosine (AMT) only when the two drugs were given at the same time; the baseline concentration of brain homovanillic acid (HVA) and its accumulation after probenecid were strongly increased by yohimbine. Yohimbine markedly decreased the concentration of brain noradrenaline (NA), both when given alone and before or at the same time as AMT; when it was given at an increasing interval after AMT, the effect became progressively smaller. The baseline concentration of brain 3-methyoxy-4-hydroxyphenylethyleneglycol sulphate and its accumulation after probenecid were increased by yohimbine; this effect was not as marked as that on HVA and was proportional to the quantity of NA depleted in the Amt method. The accumulation of brain k-hydroxyindoleacetic acid after probenecid was decreased by yohimbine pretreatment.
R Papeschi; P Theiss
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  33     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1975 Aug 
Date Detail:
Created Date:  1975-12-20     Completed Date:  1975-12-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  1-12     Citation Subset:  IM    
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MeSH Terms
Brain / drug effects,  metabolism*
Catecholamines / metabolism*
Dopamine / metabolism
Homovanillic Acid / metabolism
Hydroxyindoleacetic Acid / metabolism
Methoxyhydroxyphenylglycol / metabolism
Methyltyrosines / diagnostic use
Norepinephrine / metabolism
Probenecid / diagnostic use
Serotonin / metabolism*
Time Factors
Yohimbine / pharmacology*
Reg. No./Substance:
0/Catecholamines; 0/Methyltyrosines; 146-48-5/Yohimbine; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid; 57-66-9/Probenecid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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