| The effect of weight training on bone mineral density and bone turnover in postmenopausal breast cancer survivors with bone loss: a 24-month randomized controlled trial. | |
| | |
MedLine Citation:
|
PMID: 19802506 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
SUMMARY: This study examined whether 24 months of weight training exercises enhanced the effectiveness of risedronate, calcium, and vitamin D in maintaining or improving bone mineral density (BMD) in 223 postmenopausal breast cancer survivors. Subjects who were > or =50% adherent to exercise had no improvement in BMD but were less likely to lose BMD. INTRODUCTION: This study examined whether (1) postmenopausal breast cancer survivors (BCS) with bone loss taking 24 months of risedronate, calcium, and vitamin D had increased bone mineral density (BMD) at the total hip, femoral neck, L1-L4 spine, total radius and 33% radius, and decreased bone turnover; (2) subjects who also participated in strength/weight training (ST) exercises had greater increases in BMD and greater decreases in bone turnover; and (3) subjects who also exercised were more likely to preserve (at least maintain) BMD. METHODS: Postmenopausal BCS (223) were randomly assigned to exercise plus medication or medication only groups. Both groups received 24 months of 1,200 mg of calcium and 400 IU of vitamin D daily and 35 mg of risedronate weekly, and the exercise group additionally had ST exercises twice weekly. RESULTS: After 24 months, women who took medications without exercising had significant improvements in BMD at the total hip (+1.81%) and spine (+2.85%) and significant decreases in Alkphase B (-8.7%) and serum NTx (-16.7%). Women who also exercised had additional increases in BMD at the femoral neck (+0.29%), total hip (+0.34%), spine (+0.23%), total radius (+0.30%), and additional decreases in Alkphase B (-2.4%) and Serum NTx (-6.5%). Additional changes in BMD and bone turnover with exercise were not significant. Subjects who were > or =50% adherent to exercise were less likely to lose BMD at the total hip (chi-square [1] = 4.66, p = 0.03) and femoral neck (chi-square [1] = 4.63, p = 0.03). CONCLUSION: Strength/weight training exercises may prevent loss of BMD in postmenopausal BCS at risk for bone loss. |
| | |
Authors:
|
N L Waltman; J J Twiss; C D Ott; G J Gross; A M Lindsey; T E Moore; K Berg; K Kupzyk |
Related Documents
:
|
2917916 - Effect of exercise on the development of osteoporosis in adult rats. 15216986 - High-intensity exercise of short duration alters bovine bone density and shape. 1523956 - Monkey performance: the development of bipedalism in trained japanese monkeys. 19935856 - Serum markers of bone turnover are increased by modest weight loss with or without weig... 426086 - Total mechanical energy of a ventricle model and cardiac oxygen consumption. 17661376 - Knee extensor fatigability after bedrest for 8 weeks with and without countermeasure. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-10-03 |
Journal Detail:
|
Title: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA Volume: 21 ISSN: 1433-2965 ISO Abbreviation: Osteoporos Int Publication Date: 2010 Aug |
Date Detail:
|
Created Date: 2010-07-02 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9100105 Medline TA: Osteoporos Int Country: England |
Other Details:
|
Languages: eng Pagination: 1361-9 Citation Subset: IM |
Affiliation:
|
Lincoln Division, University of Nebraska Medical Center College of Nursing, Lincoln, NE USA. nwaltman@unmc.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
| Grant Support | |
ID/Acronym/Agency:
|
1 R01 NR07743-05A1/NR/NINR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The role of urethral hypermobility and intrinsic sphincteric deficiency on the outcome of transobtur...
Next Document: Population-based Canadian hip fracture rates with international comparisons.