Document Detail

The effect of voluntary hyperventilation on arterial blood gases and gas exchange in patients with chronic obstructive lung disease.
MedLine Citation:
PMID:  981999     Owner:  NLM     Status:  MEDLINE    
A 2 min test of voluntary hyperventilation (VHV) was performed on 19 patients with chronic obstructive lung disease (COLD) and on eight control subjects. The average decrease in PaCO2 in the patients in this test was 4.6 mmHg (11%) and the average increase in PaO2 was 12.3 mmHg (19.1%). The average decrease of PaCO2 in control subjects was 16.5 mmHg (48.6%) and the average increase in PaO2 was 38.0 mmHg (46.2%). In patients with COLD, PaCO2 changes during VHV correlated significantly with respiratory exchange ratio; the correlation with minute and alveolar ventilation and deltaVO2/deltaVE ratio during VHV was of borderline significance. PaCO2 changes during VHV did not correlate with FEV1 (percent of predicted) or FEV1/VC%. The possible mechanisms of changes in blood gas tensions during and after the end of VHV test are discussed. The VHV test seems to be useful in evaluation of patients with COLD.
J Müller; L Radwan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of respiratory diseases     Volume:  57     ISSN:  0036-5572     ISO Abbreviation:  Scand J Respir Dis     Publication Date:  1976  
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0055427     Medline TA:  Scand J Respir Dis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  129-38     Citation Subset:  IM    
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MeSH Terms
Carbon Dioxide / blood*
Chronic Disease
Forced Expiratory Volume
Lung Diseases, Obstructive / physiopathology*
Maximal Voluntary Ventilation*
Middle Aged
Oxygen / blood*
Partial Pressure
Pulmonary Ventilation*
Vital Capacity
Reg. No./Substance:
124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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