Document Detail

The effect of volume infusion on dead space in mechanically ventilated patients with severe asthma.
MedLine Citation:
PMID:  9315825     Owner:  NLM     Status:  MEDLINE    
Mechanical ventilation of patients with severe asthma is associated with elevated airway pressures that may contribute to increased physiologic dead space. To our knowledge, no previous reports have considered the effect of intravascular volume status on dead space fraction. We herein describe three patients whose dead space decreased by a mean of 4.2% in response to intravascular volume expansion with 250 or 500 mL of normal saline solution administered as part of their routine treatment. No significant changes in CO2 production, minute volume, or airway pressures occurred over the time interval. We conclude with a brief discussion of potential mechanisms to explain these findings and their potential clinical application.
C A Manthous; P Goulding
Related Documents :
6834695 - High volume, low frequency continuous ambulatory peritoneal dialysis.
14726305 - Onset of pulsatile pressure causes transiently increased filtration through artery wall.
1549965 - Estimation of right ventricular volume by modified echocardiographic subtraction method.
22209265 - Hepatic venous pressure measurements: comparison of end-hole and balloon catheter methods.
2882795 - The effect of vasoactive agents on the contractions of the initial lymphatics of the ba...
3710975 - Passive mechanics of upright human chest wall during immersion from hips to neck.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  112     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-22     Completed Date:  1997-10-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  843-6     Citation Subset:  AIM; IM    
Pulmonary and Critical Care Division, Bridgeport Hospital and Yale University School of Medicine, Conn, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Asthma / physiopathology,  therapy*
Carbon Dioxide / blood,  metabolism
Fluid Therapy
Hypercapnia / therapy
Plasma Substitutes / therapeutic use*
Positive-Pressure Respiration
Pulmonary Ventilation
Respiration / drug effects
Respiration, Artificial*
Respiratory Dead Space / drug effects*
Respiratory Insufficiency / therapy
Sodium Chloride / therapeutic use
Status Asthmaticus / therapy
Reg. No./Substance:
0/Plasma Substitutes; 124-38-9/Carbon Dioxide; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Left main coronary artery compression during primary pulmonary hypertension.
Next Document:  Respiratory failure following vinorelbine tartrate infusion in a patient with non-small cell lung ca...