Document Detail


The effect of volume infusion on dead space in mechanically ventilated patients with severe asthma.
MedLine Citation:
PMID:  9315825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mechanical ventilation of patients with severe asthma is associated with elevated airway pressures that may contribute to increased physiologic dead space. To our knowledge, no previous reports have considered the effect of intravascular volume status on dead space fraction. We herein describe three patients whose dead space decreased by a mean of 4.2% in response to intravascular volume expansion with 250 or 500 mL of normal saline solution administered as part of their routine treatment. No significant changes in CO2 production, minute volume, or airway pressures occurred over the time interval. We conclude with a brief discussion of potential mechanisms to explain these findings and their potential clinical application.
Authors:
C A Manthous; P Goulding
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  112     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-10-22     Completed Date:  1997-10-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  843-6     Citation Subset:  AIM; IM    
Affiliation:
Pulmonary and Critical Care Division, Bridgeport Hospital and Yale University School of Medicine, Conn, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Asthma / physiopathology,  therapy*
Carbon Dioxide / blood,  metabolism
Female
Fluid Therapy
Humans
Hypercapnia / therapy
Plasma Substitutes / therapeutic use*
Positive-Pressure Respiration
Pressure
Pulmonary Ventilation
Respiration / drug effects
Respiration, Artificial*
Respiratory Dead Space / drug effects*
Respiratory Insufficiency / therapy
Sodium Chloride / therapeutic use
Status Asthmaticus / therapy
Chemical
Reg. No./Substance:
0/Plasma Substitutes; 124-38-9/Carbon Dioxide; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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