Document Detail

The effect of volume expansion on placental blood flow in awake hypovolemic rats in late pregnancy.
MedLine Citation:
PMID:  2003559     Owner:  NLM     Status:  MEDLINE    
Symptomatic hypovolemia in preeclampsia is often treated by volume expansion. However, the effect of this treatment on placental blood flow is unclear. In the present study the hypothesis was tested that slow volume expansion, imposed on volume-depleted rats, does not compromise placental blood flow. Mild hypovolemia was induced in rats in late pregnancy by 24 hours' thirsting. The resulting gradual dehydration was associated with a 7% reduction in blood volume. These rats were then subjected to blood volume expansion by a continuous infusion with a plasma substitute. Volume expansion increased blood volume by 32% and cardiac output by 73%. The extra cardiac output was distributed to kidneys, carcass, and portal bed. Placental blood flow decreased by 31%. The pattern of response was comparable to the one previously observed in normovolemic rats. However, the magnitude of the changes was larger, probably associated with a delayed or impaired diuretic response. These data suggest that volume expansion therapy in mildly hypovolemic pregnant rats elicits an exaggerated hemodynamic response as compared with normovolemic rats, including placental compromise.
P F Boekkooi; C M Verkeste; L L Peeters
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  164     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-04-15     Completed Date:  1991-04-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  921-6     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, University of Limburg, Maastricht, The Netherlands.
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MeSH Terms
Blood Volume*
Placenta / blood supply*
Pre-Eclampsia / therapy
Rats, Inbred Strains

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