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The effect of vitamin E on tracheal responsiveness and lung inflammation in sulfur mustard exposed guinea pigs.
MedLine Citation:
PMID:  21391784     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Pulmonary complications of sulfur mustard (SM) range from mild respiratory symptoms to even severe bronchial stenosis. In the present study, the protective effect of vitamin E on tracheal responsiveness (TR) and lung inflammation of SM-exposed guinea pigs were examined. Guinea pigs were exposed to ethanol (control group), 40 mg/m(3) inhaled SM and ethanol vehicle (sulfur mustard exposed (SME) group), SME treated with vitamin E (SME + E), SME with dexamethasone (SME + D) and both drugs (SME + E + D), (n = 8 for each group). TR to methacholine, total and differential white blood cell (WBC) count of lung lavage and serum cytokines were evaluated 14 days post-exposure. TR, WBC, interleukin 4 (IL-4), interferon gamma (INF-γ), eosinophil, and monocyte levels in SME guinea pigs were significantly higher, but lymphocyte was lower than those of controls (P < 0.05 to P < 0.001). TR, IL-4, and eosinophil levels in SME + E, SME + D and SME + E + D, INF-γ in SME + E and SME + E + D and WBC in SME + E were significantly decreased compared to that of the SME group (P < 0.01 to P < 0.001). In addition, the TR of SME + D + E was significantly higher than that of SME + E (P < 0.01) and SME + D (P < 0.05) groups. The results showed a preventive effect of vitamin E, dexamethasone and their combination on TR and lung inflammation in SME guinea pigs.
Authors:
Mohammad Hossein Boskabady; Sediqa Amery; Nassim Vahedi; Mohammad Reza Khakzad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Inhalation toxicology     Volume:  23     ISSN:  1091-7691     ISO Abbreviation:  Inhal Toxicol     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8910739     Medline TA:  Inhal Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  157-65     Citation Subset:  IM    
Affiliation:
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.
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