Document Detail


The effect of verapamil on myocardial exchange of free fatty acids, citrate, lactate and glucose in coronary artery disease.
MedLine Citation:
PMID:  6617687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twelve patients with coronary artery stenosis (greater than 50% diameter reduction) underwent two identical periods of atrial pacing before and after i.v. verapamil (0.1 mg/kg). Myocardial exchanges of free fatty acids (FFA), citrate, lactate and glucose were evaluated from measurements of arterio-coronary sinus differences (n = 12) and coronary sinus blood flow (CSBF) (n = 9). Before verapamil 11 patients developed angina. Verapamil abolished pain in seven and improved pacing time to angina in four patients. After verapamil, aortic pressure decreased (P less than 0.05), while the rate pressure product remained unchanged during rest and pacing. Verapamil decreased CSBF by 20% (P less than 0.05) during pacing, and increased oxygen extraction both during pacing and recovery. During pacing verapamil increase net FFA extraction (P less than 0.01) and uptake (1 to 8 mumol/min P less than 0.05), and decreased glucose extraction (P less than 0.05) and uptake (22 to 11 mumol/min P less than 0.02. Verapamil increased myocardial citrate release during pacing (P less than 0.05), suggesting a citrate inhibition of glycolysis as a possible mechanism of the inhibited glucose uptake. During pacing, verapamil reduced lactate release in seven patients (P less than 0.05) and decreased lactate extraction in five patients (P less than 0.05). The results suggest that verapamil mediates its beneficial effect on pacing-induced angina, in part by changing substrate utilization of the ischaemic myocardium in man towards that of normal heart.
Authors:
J P Bagger; T T Nielsen; P Henningsen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European heart journal     Volume:  4     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  1983 Jun 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  406-14     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Citrates / metabolism
Coronary Circulation
Coronary Disease / drug therapy*,  physiopathology
Fatty Acids, Nonesterified / metabolism
Glucose / metabolism
Humans
Lactates / metabolism
Male
Middle Aged
Myocardium / metabolism*
Oxygen Consumption
Verapamil / therapeutic use*
Chemical
Reg. No./Substance:
0/Citrates; 0/Fatty Acids, Nonesterified; 0/Lactates; 50-99-7/Glucose; 52-53-9/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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