Document Detail

The effect of vasopressin V1- and V2-receptor antagonists on hemodynamics in early and late phase after myocardial infarction in rats.
MedLine Citation:
PMID:  9829627     Owner:  NLM     Status:  MEDLINE    
This study was designed to assess the effect of a nonpeptide vasopressin V1-receptor antagonist, OPC-21268, and a vasopressin V2-receptor antagonist, OPC-31260, on hemodynamics in the early phase and the late phase after myocardial infarction in rats. In the early phase, OPC-21268 (30 mg/kg/day) or OPC-31260 (30 mg/kg/day) was orally administered from day 1 to day 5 after the operation; and hemodynamics were measured at day 5, in the late phase from 10 weeks to 11 weeks and measured at the end of 11 weeks. In the early phase, OPC-21268 reduced the left ventricular end-diastolic pressure (LVEDP) concomitantly with the reduction in systemic blood pressure, but did not change LVEDP in the late phase. OPC-31260 reduced LVEDP and central venous pressure in both phases. OPC-21268 improved hemodynamics only in the early phase and OPC-31260 improved it in both phases.
H Fujita; M Yoshiyama; K Takeuchi; T Omura; H Yamagishi; H Iwao; K Miura; J Yoshikawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese journal of pharmacology     Volume:  78     ISSN:  0021-5198     ISO Abbreviation:  Jpn. J. Pharmacol.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-01-14     Completed Date:  1999-01-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2983305R     Medline TA:  Jpn J Pharmacol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  229-32     Citation Subset:  IM    
First Department of Internal Medicine, Osaka City University Medical School, Japan.
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MeSH Terms
Administration, Oral
Benzazepines / pharmacology*,  therapeutic use
Heart Ventricles / anatomy & histology
Hemodynamics / drug effects*
Myocardial Infarction / blood,  drug therapy*,  physiopathology
Organ Size / drug effects
Piperidines / pharmacology*,  therapeutic use
Quinolones / pharmacology*,  therapeutic use
Rats, Wistar
Receptors, Vasopressin / antagonists & inhibitors*
Time Factors
Vasopressins / blood,  drug effects
Ventricular Function, Left / drug effects
Reg. No./Substance:
0/Benzazepines; 0/Piperidines; 0/Quinolones; 0/Receptors, Vasopressin; 11000-17-2/Vasopressins; 131631-89-5/OPC 21268; 137975-06-5/OPC 31260

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