Document Detail

The effect of vaginal pH on the efficacy of vaginal misoprostol for induction of labor.
MedLine Citation:
PMID:  10746843     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Misoprostol was reported to be an effective agent for cervical ripening and induction of labor. Our purpose was to evaluate whether vaginal pH affected the efficacy of misoprostol for induction of labor. METHODS: The vaginal pH of 103 women admitted for induction of labor were measured. According to the vaginal pH, two groups were generated, those with a vaginal pH <5 (n= 65), and those with a vaginal pH > or =5 (n=38). All women received intravaginal misoprostol tablets, 50 microg every 4 hours up to three doses. Further medication was not given after entry into active labor or spontaneous rupture of membranes. In cases of failed induction or arrest disorders oxytocin augmentation was used. RESULTS: The average interval from start of induction to vaginal delivery was shorter, and oxytocin augmentation was required less commonly in the lower pH group. We did not find any significant difference in cesarean section rates, or incidence of adverse maternal or fetal outcome. CONCLUSION: Vaginal pH may affect the pharmacokinetics of vaginally administered misoprostol, and may cause an alteration in induction to delivery interval.
S Gunalp; I Bildirici
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  79     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-04-14     Completed Date:  2000-04-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  283-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Hacettepe University School of Medicine, Ankara, Turkey.
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MeSH Terms
Administration, Intravaginal
Hydrogen-Ion Concentration
Labor, Induced*
Misoprostol / pharmacokinetics*,  pharmacology
Oxytocics / pharmacokinetics*,  pharmacology
Vagina / chemistry*
Reg. No./Substance:
0/Oxytocics; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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