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The effect of using an alternative irrigant between sodium hypochlorite and chlorhexidine to prevent the formation of para-chloroaniline within the root canal system.
MedLine Citation:
PMID:  22486894     Owner:  NLM     Status:  Publisher    
Mortenson D, Sadilek M, Flake NM, Paranjpe A, Heling I, Johnson JD, Cohenca N. The effect of using an alternative irrigant between sodium hypochlorite and chlorhexidine to prevent the formation of para-chloroaniline within the root canal system. International Endodontic Journal. ABSTRACT: Aim  To determine if the formation of para-chloroaniline (PCA) can be avoided by using an alternative irrigant following sodium hypochlorite but before chlorhexidine. Methodology  Fifty-five single-rooted teeth were decoronated, instrumented to size 40, .06 taper whilst being irrigated with 14% ethylene-diamine-tetra-acetic acid (EDTA) and 6% NaOCl. Samples were then randomly divided into three experimental and two control groups. Group 1 was irrigated with saline followed by 2% chlorhexidine gluconate (CHX). Group 2 was irrigated with 50% citric acid (CA) followed by 2% CHX. Group 3 was irrigated with 14% EDTA followed by 2% CHX. The chemical identity and quantification of the PCA in the formed precipitate was determined using gas chromatography/mass spectrometry (GC/MS). Results  All experimental groups contained PCA. The mean level of PCA for group 1 (sterile saline) was 229 ng mL(-1) , group 2 (citric acid) 72 ng mL(-1) and group 3 (EDTA) 400 ng mL(-1) , respectively. A significant difference was found between the saline and EDTA groups and the negative control (P < 0.05). Although no statistical significance was found between the negative control and citric acid group, PCA was still present in this experimental group. Conclusions  Citric acid used as the intermittent irrigant had the least amount of PCA formation in the canal system. Until the threshold required to cause biological damage in humans is determined, the combination of NaOCl and CHX in root canal treatment should be avoided.
D Mortenson; M Sadilek; N M Flake; A Paranjpe; I Heling; J D Johnson; N Cohenca
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-19
Journal Detail:
Title:  International endodontic journal     Volume:  -     ISSN:  1365-2591     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-4-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004996     Medline TA:  Int Endod J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 International Endodontic Journal.
Department of Endodontics, School of Dentistry, University of Washington, Seattle, WA Department of Chemistry, University of Washington, Seattle, WA, USA Department of Endodontics, School of Dental Medicine, Hadassah-Hebrew University, Jerusalem, Israel.
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