Document Detail

The effect of universal maternal screening on the incidence of neonatal early-onset group B streptococcal disease.
MedLine Citation:
PMID:  18832528     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the effect of the revised guidelines on incidence of neonatal early-onset group B streptococcal disease (EoGBS) via retrospective analysis of births in a military population. METHODS: Information from records of all live births within military hospitals from 1993 to 2007 was obtained. The data were divided into three time frames, representing the evolution of identifying and managing at-risk deliveries for GBS transmission. Incidence of EoGBS decreased from 1.95 to 0.72 per 1000 live births following institution of the 1996 Centers for Disease Control and Prevention recommendations and continued to fall to 0.47 per 1000 since the adoption of universal screening in 2002. CONCLUSIONS: Universal culture-based screening is more effective than risk-based screening in preventing EoGBS in term infants. Cases of EoGBS continue to occur, however, at a baseline rate of nearly 0.5 per 1000 births, thus emphasizing the need for rapid diagnostics and ultimately a vaccine.
Matthew D Eberly; Michael Rajnik
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Publication Detail:
Type:  Journal Article     Date:  2008-10-02
Journal Detail:
Title:  Clinical pediatrics     Volume:  48     ISSN:  0009-9228     ISO Abbreviation:  Clin Pediatr (Phila)     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-16     Completed Date:  2009-06-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  369-75     Citation Subset:  AIM; IM    
Department of Pediatrics, F. Edward Hebert School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814-4712, USA.
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MeSH Terms
Anti-Bacterial Agents / therapeutic use
Antibiotic Prophylaxis
Carrier State / drug therapy
Gestational Age
Infant, Newborn
Infant, Newborn, Diseases / epidemiology*,  microbiology,  prevention & control
Infectious Disease Transmission, Vertical / prevention & control,  statistics & numerical data*
Mass Screening / statistics & numerical data*
Mothers / statistics & numerical data
Practice Guidelines as Topic
Pregnancy Complications, Infectious / microbiology
Prenatal Care / methods,  standards
Program Evaluation
Retrospective Studies
Streptococcal Infections / epidemiology*,  microbiology,  transmission*
Streptococcus agalactiae*
Treatment Outcome
Reg. No./Substance:
0/Anti-Bacterial Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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