Document Detail


The effect of unilateral superior laryngeal nerve lesion on swallowing threshold volume.
MedLine Citation:
PMID:  23670486     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES/HYPOTHESIS: The superior laryngeal nerve (SLN) is the major sensory nerve for the upper larynx. Damage to this nerve impacts successful swallowing. The first aim of the study was to assess the effect of unilateral SLN lesion on the threshold volume sufficient to elicit swallowing in an intact pig model; this volume was defined radiographically as the maximum bolus area visible in lateral view. The second aim was to determine if a difference existed between ipsilateral and contralateral function as a result of unilateral sensory loss, measured as the radiologic density of fluid seen in the valleculae. Finally, we determined whether there was a relationship between the threshold volume and the occurrence of aspiration after a unilateral SLN lesion.
STUDY DESIGN: Repeated measures animal study.
METHODS: Four female infant pigs underwent unilateral SLN lesion surgery. The maximum vallecular bolus area in lateral view and the relative vallecular density on each side in the dorsoventral view were obtained from videofluoroscopic recordings in both the prelesion control and postlesion experimental states.
RESULTS: In lateral view, the lesioned group had a larger maximum bolus area than the control group (P < .001). Although occasional left-right asymmetry in the dorsoventral view was observed, the vallecular densities were, on average, equal on both the left (intact) and right (lesioned) sides (P > .05). A bigger maximum bolus area did not predict aspiration in the lesioned group (P > .05).
CONCLUSIONS: Unilateral SLN lesions increased the swallowing threshold volume symmetrically in right and left valleculae, but the increased threshold may not be the main mechanism for the occurrence of aspiration.
Authors:
Peng Ding; Regina Campbell-Malone; Shaina D Holman; Stacey L Lukasik; Allan J Thexton; Rebecca Z German
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-05-13
Journal Detail:
Title:  The Laryngoscope     Volume:  123     ISSN:  1531-4995     ISO Abbreviation:  Laryngoscope     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-22     Completed Date:  2013-09-30     Revised Date:  2014-11-11    
Medline Journal Info:
Nlm Unique ID:  8607378     Medline TA:  Laryngoscope     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1942-7     Citation Subset:  IM    
Copyright Information:
© 2013 The American Laryngological, Rhinological and Otological Society, Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Deglutition / physiology*
Female
Fluoroscopy
Laryngeal Nerves / physiology*,  radiography
Larynx / physiology*,  radiography
Swine
Video Recording
Grant Support
ID/Acronym/Agency:
DC9980/DC/NIDCD NIH HHS; F30 DE021944/DE/NIDCR NIH HHS; R01 DC009980/DC/NIDCD NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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