| The effect of the undigested fraction of maize products on the activity and composition of the microbiota determined in a dynamic in vitro model of the human proximal large intestine. | |
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MedLine Citation:
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PMID: 20516265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the effect of 5 newly developed maize-based fibers on the activity and composition of the microbiota in the colon. The fibers tested were glucose-based and had variable structures, including 2 resistant starch preparations, soluble corn fiber, pullulan, and soluble fiber dextrin. METHODS: The fibers were predigested, mono- and disaccharides were removed, and the residual polymer was used to assess the production of microbial metabolites and changes in composition of the microbiota using a dynamic, validated, in vitro model of the large intestine. RESULTS: Microbial metabolite analysis showed an increase in short-chain fatty acids for all fibers, with varying levels of butyrate production for each fiber. The greatest increase of butyrate, both in terms of absolute amounts and as a proportion of total short-chain fatty acids, was observed for pullulan. All fibers also reduced toxic metabolites from protein fermentation compared to the poorly fermentable control (cellulose). Microbial composition was assessed using a micro-array platform. All fibers showed increases of bifidobacteria and some Lactobacillus species, although different species were stimulated by different fibers. Pullulan showed the largest increase of bifidobacteria. CONCLUSIONS: All fibers showed prebiotic activity in terms of increases in growth and/or activity of beneficial microbes. In addition, compared to the control, health-promoting metabolites were produced in higher amounts, while putrefactive metabolites were reduced for all fibers. The importance of the findings lies in the fact that the newly developed, maize-based fibers shift the intestinal environment to a healthier milieu, with increased health-promoting metabolites and health-beneficial microbes. |
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Authors:
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Annet Maathuis; Andrew Hoffman; Annette Evans; Lisa Sanders; Koen Venema |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Nutrition Volume: 28 ISSN: 1541-1087 ISO Abbreviation: J Am Coll Nutr Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-06-02 Completed Date: 2010-08-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8215879 Medline TA: J Am Coll Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 657-66 Citation Subset: IM |
Affiliation:
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Department of Biosciences, TNO Quality of Life, P3700 AJ Zeist, The Netherlands. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bifidobacterium
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metabolism Digestion / physiology* Humans Intestine, Large / metabolism*, microbiology* Metagenome Zea mays / metabolism* |
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