Document Detail


The effect of ultraviolet B-induced vitamin D levels on host resistance to Mycobacterium tuberculosis: a pilot study in immigrant Asian adults living in the United Kingdom.
MedLine Citation:
PMID:  18353091     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Asian immigrants to the United Kingdom demonstrate much higher tuberculosis rates than the indigenous population. This is postulated to be because of their low vitamin D levels, consequent upon a combination of diet and their reduced ultraviolet (UV) exposure in the United Kingdom, because vitamin D enhances antimycobacterial activity in in vitro systems. The aim of this study was to examine the relationship between UVB exposure, vitamin D levels and tuberculo-immunity in Asian immigrants in the United Kingdom. Suberythemal UVB treatments were given to eight subjects on 3 consecutive days, using broadband UVB fluorescent lamps. Blood was sampled for 25-hydroxyvitamin D (25-OH D) and whole blood functional assays were performed for antimycobacterial immunity. The mean 25-OH D level increased from a baseline of 11.23 ng/ml (95% CI 6.7-20.39) to 20.39 ng/ml (95% CI 16.6-20) following UVB treatment, P<0.01. However, no significant change in antimycobacterial immunity occurred following UVB exposure. This pilot study in Asian subjects with good baseline tuberculo-immunity has not supported a role for UVB-induced 25-OH D in the immune response to Mycobacterium tuberculosis.
Authors:
Paul Devakar Yesudian; Jacqueline Lesley Berry; Siouxsie Wiles; Stefan Hoyle; Douglas Brownlie Young; Ann Katarina Haylett; Lesley Elizabeth Rhodes; Peter Davies
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Photodermatology, photoimmunology & photomedicine     Volume:  24     ISSN:  1600-0781     ISO Abbreviation:  Photodermatol Photoimmunol Photomed     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-20     Completed Date:  2008-04-15     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  9013641     Medline TA:  Photodermatol Photoimmunol Photomed     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  97-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Asia / ethnology
Dose-Response Relationship, Radiation
Emigration and Immigration
Female
Great Britain
Humans
Immunity, Innate
Male
Mycobacterium tuberculosis / immunology*
Pilot Projects
Skin / metabolism,  radiation effects*
Tuberculosis, Pulmonary / immunology*,  microbiology
Ultraviolet Rays*
Vitamin D / biosynthesis*
Grant Support
ID/Acronym/Agency:
MC_U117581288//Medical Research Council
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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