| The effect of ultraviolet B-induced vitamin D levels on host resistance to Mycobacterium tuberculosis: a pilot study in immigrant Asian adults living in the United Kingdom. | |
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MedLine Citation:
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PMID: 18353091 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Asian immigrants to the United Kingdom demonstrate much higher tuberculosis rates than the indigenous population. This is postulated to be because of their low vitamin D levels, consequent upon a combination of diet and their reduced ultraviolet (UV) exposure in the United Kingdom, because vitamin D enhances antimycobacterial activity in in vitro systems. The aim of this study was to examine the relationship between UVB exposure, vitamin D levels and tuberculo-immunity in Asian immigrants in the United Kingdom. Suberythemal UVB treatments were given to eight subjects on 3 consecutive days, using broadband UVB fluorescent lamps. Blood was sampled for 25-hydroxyvitamin D (25-OH D) and whole blood functional assays were performed for antimycobacterial immunity. The mean 25-OH D level increased from a baseline of 11.23 ng/ml (95% CI 6.7-20.39) to 20.39 ng/ml (95% CI 16.6-20) following UVB treatment, P<0.01. However, no significant change in antimycobacterial immunity occurred following UVB exposure. This pilot study in Asian subjects with good baseline tuberculo-immunity has not supported a role for UVB-induced 25-OH D in the immune response to Mycobacterium tuberculosis. |
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Authors:
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Paul Devakar Yesudian; Jacqueline Lesley Berry; Siouxsie Wiles; Stefan Hoyle; Douglas Brownlie Young; Ann Katarina Haylett; Lesley Elizabeth Rhodes; Peter Davies |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Photodermatology, photoimmunology & photomedicine Volume: 24 ISSN: 1600-0781 ISO Abbreviation: Photodermatol Photoimmunol Photomed Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-20 Completed Date: 2008-04-15 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9013641 Medline TA: Photodermatol Photoimmunol Photomed Country: Denmark |
Other Details:
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Languages: eng Pagination: 97-8 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Royal Liverpool University Hospital, Liverpool, UK. paul.yesudian@coch.nhs.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Asia / ethnology Dose-Response Relationship, Radiation Emigration and Immigration Female Great Britain Humans Immunity, Innate Male Mycobacterium tuberculosis / immunology* Pilot Projects Skin / metabolism, radiation effects* Tuberculosis, Pulmonary / immunology*, microbiology Ultraviolet Rays* Vitamin D / biosynthesis* |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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