| The effect of tuberculin skin test and BCG vaccination on the expansion of PPD-specific IFN-gamma producing cells ex vivo. | |
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MedLine Citation:
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PMID: 18023944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Understanding the immunogenicity of BCG in a population where it has failed will facilitate the design of new TB vaccines. We assessed the immunogenicity of M. bovis BCG over 12 months by ELISPOT assay. Forty-one adolescents and young Gambian male adults received a tuberculin skin test (TST) which was followed one week later by BCG vaccination, but the 23 control subjects received neither of these. TST alone significantly induced PPD-specific IFN-gamma producing cells. Twenty-three percent of subjects did not respond to BCG, which was associated with higher pre-existing ex vivo response to PPD. Paradoxically, amongst BCG responders there was a correlation between pre-existing response and subsequent response to BCG. We conclude that BCG is immunogenic, but this effector response is short-lived and can be limited in higher pre-existing anti-mycobacterial immunity, suggesting a possible threshold beyond which BCG immunogenicity is inhibited. |
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Authors:
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Martin O C Ota; Roger H Brookes; Philip C Hill; Patrick K Owiafe; Hannah B Ibanga; Simon Donkor; Timothy Awine; Helen McShane; Richard A Adegbola |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-10-31 |
Journal Detail:
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Title: Vaccine Volume: 25 ISSN: 0264-410X ISO Abbreviation: Vaccine Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2007-12-10 Completed Date: 2008-02-21 Revised Date: 2010-05-07 |
Medline Journal Info:
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Nlm Unique ID: 8406899 Medline TA: Vaccine Country: Netherlands |
Other Details:
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Languages: eng Pagination: 8861-7 Citation Subset: IM |
Affiliation:
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Bacterial Diseases Programme, Medical Research Council, P.O. Box 273, Banjul, Gambia. mota@mrc.gm |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Cells, Cultured Gambia Humans Interferon-gamma / biosynthesis* Leukocytes, Mononuclear / immunology Lymphocytes / immunology* Male Mycobacterium bovis / immunology* Tuberculin Test* Tuberculosis Vaccines / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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076943//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Tuberculosis Vaccines; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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