Document Detail

The effect of triclosan-coated sutures in wound healing. A double blind randomised prospective pilot study.
MedLine Citation:
PMID:  18450530     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Wound infection and dehiscence are both major contributors to postoperative morbidity. One potential cause or co-factor is the use of suture material. A recently introduced subcutaneous suture is coated with triclosan (TC), an antiseptic drug. It is suggested to reduce wound complications. METHODS: To investigate the effect of TC on wound healing a double blind prospective pilot study in women undergoing a breast reduction was performed. Each patient was her own control. After randomisation the TC-coated sutures were used either on the left or right side. The contralateral side was used as the control. The incidence of dehiscence was studied. RESULTS: Twenty-six patients were included. In the TC breasts there was a wound dehiscence in 16 cases, whereas in the control breasts in seven cases a dehiscence was observed (P=0.023). CONCLUSION: These results suggest that TC-coated sutures should be used with caution. These sutures have already been introduced on to the market without good clinical studies and might have potential adverse effects as shown by these data.
An E Deliaert; Eric Van den Kerckhove; Stefania Tuinder; Steffen Fieuws; John H Sawor; Marleen A Meesters-Caberg; Rene R van der Hulst
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2008-05-02
Journal Detail:
Title:  Journal of plastic, reconstructive & aesthetic surgery : JPRAS     Volume:  62     ISSN:  1878-0539     ISO Abbreviation:  -     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-25     Completed Date:  2009-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264239     Medline TA:  J Plast Reconstr Aesthet Surg     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  771-3     Citation Subset:  IM    
Department of Plastic Surgery, University Hospital Maastricht, Maastricht, The Netherlands.
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MeSH Terms
Anti-Infective Agents, Local / adverse effects,  pharmacology*,  therapeutic use
Double-Blind Method
Middle Aged
Pilot Projects
Surgical Wound Dehiscence / chemically induced
Surgical Wound Infection / prevention & control
Triclosan / adverse effects,  pharmacology*,  therapeutic use
Wound Healing / drug effects*
Young Adult
Reg. No./Substance:
0/Anti-Infective Agents, Local; 3380-34-5/Triclosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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