Document Detail


The effect of transcutaneous electrical nerve stimulation on coronary and systemic haemodynamics in syndrome X.
MedLine Citation:
PMID:  8913674     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Neurostimulation techniques have been shown to be beneficial in patients with angina and syndrome X but the mechanism remains unclear. We examined the effect of transcutaneous electrical nerve stimulation (TENS) on coronary artery blood flow in a group of patients with syndrome X. METHODS: Coronary blood flows were measured in 11 patients with angiographically normal coronary arteries, positive results from exercise tests and angina (syndrome X) using intracoronary Doppler catheters combined with quantitative coronary angiography. RESULTS: The mean coronary flow velocity did not increase in any patient during TENS therapy; in fact, there was a fall from 5.2 +/- 2.8 to 4.3 +/- 1.9 cm/s (P = 0.02) and the coronary blood flow index fell from 47 +/- 22 to 38 +/- 16 cm/s per mm2 (P = 0.007). This was associated with a fall in the rate x pressure product from 0.92 +/- 0.22 to 0.83 +/- 0.18 mmHg/min (P = 0.038). The coronary vascular resistance rose from 2.4 +/- 1.1 to 3.0 +/- 1.6 mmHg/cm per s per mm2 (P = 0.041). There were no major changes in the epicardial coronary artery diameter during TENS and there was no significant effect on the response to the cold-pressor test. CONCLUSIONS: In this group of patients with syndrome X, TENS produced a small but significant fall in coronary artery blood flow associated with a reduction in the rate x pressure product. TENS had no significant effect on coronary vasomotion during sympathetic stimulation by the cold-pressor test. Thus, TENS is unlikely to have a direct effect on coronary artery vasomotion or haemodynamics in syndrome X but reduces the rate x pressure product and thus myocardial oxygen consumption.
Authors:
J E Sanderson; K S Woo; H K Chung; W W Chan; L K Tse; H D White
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Coronary artery disease     Volume:  7     ISSN:  0954-6928     ISO Abbreviation:  Coron. Artery Dis.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1997-02-10     Completed Date:  1997-02-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9011445     Medline TA:  Coron Artery Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  547-52     Citation Subset:  IM    
Affiliation:
Department of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
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MeSH Terms
Descriptor/Qualifier:
Blood Flow Velocity
Coronary Circulation*
Heart Rate
Hemodynamics*
Humans
Microvascular Angina / drug therapy,  physiopathology*,  therapy*
Nitroglycerin / administration & dosage
Transcutaneous Electric Nerve Stimulation* / methods
Vascular Resistance
Chemical
Reg. No./Substance:
55-63-0/Nitroglycerin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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