| The effect of trans-ferulic acid and gamma-oryzanol on ethanol-induced liver injury in C57BL mouse. | |
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MedLine Citation:
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PMID: 18424018 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The effects of the oral administration of trans-ferulic acid and gamma-oryzanol (mixture of steryl ferulates) with ethanol (5.0gperkg) for 30 days to c57BL mice on ethanol-induced liver injury were investigated. Preventions of ethanol-induced liver injury by trans-ferulic acid and gamma-oryzanol were reflected by markedly decreased serum activities of plasma aspartate aminotransferase, alanine aminotransferase and significant decreases in hepatic lipid hydroperoxide and TBARS levels. Furthermore, the trans-ferulic acid- and gamma-oryzanol-treated mice recovered ethanol-induced decrease in hepatic glutathione level together with enhancing superoxide dismutase activity. These results demonstrate that both trans-ferulic acid and gamma-oryzanol exert a protective action on liver injury induced by chronic ethanol ingestion. |
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Authors:
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Chatchawan Chotimarkorn; Hideki Ushio |
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Publication Detail:
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Type: Journal Article Date: 2008-04-18 |
Journal Detail:
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Title: Phytomedicine : international journal of phytotherapy and phytopharmacology Volume: 15 ISSN: 0944-7113 ISO Abbreviation: Phytomedicine Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2012-05-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9438794 Medline TA: Phytomedicine Country: Germany |
Other Details:
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Languages: eng Pagination: 951-8 Citation Subset: IM |
Affiliation:
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Department of Food Science and Technology, Tokyo University of Marine Science and Technology, 5-7 Konan 4, Minato, Tokyo 108-8477, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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