Document Detail


The effect of tranexamic acid on bleeding time and haemostasis.
MedLine Citation:
PMID:  1745318     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of tranexamic acid (TXA) on platelet function was examined in 37 patients with ruptured intracranial aneurysms. TXA was administered in a double-blind, placebo controlled manner to 37 patients with ruptured intracranial aneurysms. TXA was given to 17 patients in a dose of 9 g/24 hours, to another 6 patients in a dose of 6 g/24 hours; 14 patients were given a placebo. The effect of TXA on certain haemostatic function tests was evaluated between the treatment groups. We conclude that patients receiving TXA do not appear to be at risk of recurrent haemorrhage due to abnormal haemostasis.
Authors:
S A Menzies; J A Hartley; E R Hitchcock; E Rorke; J S Gill
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurochirurgia     Volume:  34     ISSN:  0028-3819     ISO Abbreviation:  Neurochirurgia (Stuttg)     Publication Date:  1991 Sep 
Date Detail:
Created Date:  1992-01-10     Completed Date:  1992-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400774     Medline TA:  Neurochirurgia (Stuttg)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  141-3     Citation Subset:  IM    
Affiliation:
University Department of Neurosurgery and Haematology, Midland Centre for Neurosurgery and Neurology, Birmingham, England.
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MeSH Terms
Descriptor/Qualifier:
Bleeding Time*
Blood Coagulation Tests
Drug Administration Schedule
Hemostasis / drug effects*,  physiology
Humans
Infusions, Intravenous
Intracranial Aneurysm / blood,  drug therapy*
Platelet Adhesiveness / drug effects,  physiology
Platelet Aggregation / drug effects,  physiology
Platelet Count / drug effects
Subarachnoid Hemorrhage / blood,  drug therapy*
Tranexamic Acid* / administration & dosage*
Chemical
Reg. No./Substance:
1197-18-8/Tranexamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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