| The effect of tranexamic acid on bleeding time and haemostasis. | |
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MedLine Citation:
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PMID: 1745318 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of tranexamic acid (TXA) on platelet function was examined in 37 patients with ruptured intracranial aneurysms. TXA was administered in a double-blind, placebo controlled manner to 37 patients with ruptured intracranial aneurysms. TXA was given to 17 patients in a dose of 9 g/24 hours, to another 6 patients in a dose of 6 g/24 hours; 14 patients were given a placebo. The effect of TXA on certain haemostatic function tests was evaluated between the treatment groups. We conclude that patients receiving TXA do not appear to be at risk of recurrent haemorrhage due to abnormal haemostasis. |
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Authors:
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S A Menzies; J A Hartley; E R Hitchcock; E Rorke; J S Gill |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurochirurgia Volume: 34 ISSN: 0028-3819 ISO Abbreviation: Neurochirurgia (Stuttg) Publication Date: 1991 Sep |
Date Detail:
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Created Date: 1992-01-10 Completed Date: 1992-01-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0400774 Medline TA: Neurochirurgia (Stuttg) Country: GERMANY |
Other Details:
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Languages: eng Pagination: 141-3 Citation Subset: IM |
Affiliation:
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University Department of Neurosurgery and Haematology, Midland Centre for Neurosurgery and Neurology, Birmingham, England. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bleeding Time* Blood Coagulation Tests Drug Administration Schedule Hemostasis / drug effects*, physiology Humans Infusions, Intravenous Intracranial Aneurysm / blood, drug therapy* Platelet Adhesiveness / drug effects, physiology Platelet Aggregation / drug effects, physiology Platelet Count / drug effects Subarachnoid Hemorrhage / blood, drug therapy* Tranexamic Acid* / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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1197-18-8/Tranexamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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