| The effect of topical caffeine on the morphology of swine hypodermis as measured by ultrasound. | |
| | |
MedLine Citation:
|
PMID: 18789063 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Cellulite or lipodystrophy involves the modification of the subcutaneous adipose tissue. A wide variety of topical products is available to combat cellulite, but these have difficulties in being absorbed through the skin. One option is the therapeutic use of the ultrasound to enhance the trans-dermic transport of these drugs. AIM: The objective of this study was the analysis of the effect of caffeine on the morphology of the swine hypodermis, both when applied topically and in combination with ultrasound treatment. METHODS: The following treatments were applied to the dorsal areas of five pigs (Landrace x Large White, 35 days old, weighing 15 kg each): gel, gel + ultrasound, gel + caffeine (5%, w/w), and gel + caffeine + ultrasound, daily for 15 days. A fifth area received no topical application and was used as a control. Continuous ultrasound of 3 MHz with an intensity of 0.2 W/cm(2) was applied at a rate of 1 min/cm(2). After histological processing (hematoxylin and eosin), morphometric analyses were conducted to determine the thickness and numerical profile of the hypodermis. A one-way analysis variance using a Kolmogorov-Smirnov test was conducted, with a Tukey test used to identify significant differences. A confidence level of P < or = 0.05 was adopted. RESULTS: Caffeine treatment was effective only when associated with ultrasound therapy; the combination resulted in a significant reduction in the thickness of the subcutaneous adipose tissue, as well as damage to the adipocytes, consequently decreasing the number of cells. CONCLUSION: Ultrasound treatment was effective in increasing the cutaneous permeation of caffeine, as evidenced by the reduction in thickness of the hypodermis and number of adipocytes. |
| | |
Authors:
|
Maria Silvia Mariani Pires-de-Campos; Gislaine Ricci Leonardi; Marlus Chorilli; Regina Célia Spadari-Bratfisch; Maria Luiza Ozores Polacow; Dora Maria Grassi-Kassisse |
Related Documents
:
|
10797123 - Muscle glycogen resynthesis during recovery from cycle exercise: no effect of additiona... 7874153 - Comparison between carbohydrate feedings before and during exercise on running performa... 3354463 - Left ventricular dysfunction after prolonged strenuous exercise in healthy subjects. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of cosmetic dermatology Volume: 7 ISSN: 1473-2165 ISO Abbreviation: J Cosmet Dermatol Publication Date: 2008 Sep |
Date Detail:
|
Created Date: 2008-09-15 Completed Date: 2009-01-09 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101130964 Medline TA: J Cosmet Dermatol Country: England |
Other Details:
|
Languages: eng Pagination: 232-7 Citation Subset: IM |
Affiliation:
|
LABEEST, Laboratory of Stress Study, Department of Biophysics and Physiology, Institute of Biology, State University of Campinas, Campinas, São Paulo, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Cutaneous Animals Caffeine / administration & dosage*, pharmacology* Central Nervous System Stimulants / administration & dosage*, pharmacology* Data Interpretation, Statistical Male Propylene Glycol / administration & dosage, pharmacology Solvents / administration & dosage, pharmacology Statistics, Nonparametric Subcutaneous Tissue / drug effects*, ultrasonography* Sus scrofa Swine Treatment Outcome Ultrasonic Therapy / methods |
| Chemical | |
Reg. No./Substance:
|
0/Central Nervous System Stimulants; 0/Solvents; 57-55-6/Propylene Glycol; 58-08-2/Caffeine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Facial scars after a road accident--combined treatment with pulsed dye laser and Q-switched Nd:YAG l...
Next Document: Dermal and epidermal remodeling using botulinum toxin type A for facial, nonreducible, hyperkinetic ...