Document Detail

The effect of topical 2.5% phenylephrine and 1% tropicamide on systemic blood pressure and pulse.
MedLine Citation:
PMID:  3711577     Owner:  NLM     Status:  MEDLINE    
A prospective double-blind trial is described in which patients were given either 1% tropicamide, 2.5% phenylephrine, a combination of the two drugs, or a placebo. Blood pressure measurements and pulse rates were determined at 5, 10 and 15 minute intervals post-instillation. No significant change in systolic or diastolic blood pressures were determined for any of the treatment groups at any of the time intervals; however, a slight but significant decrease in pulse rate was noted in some of the treatment groups. The data are analyzed according to other variables. Factors which may have influenced the findings are discussed.
B J Jennings; D E Sullivan
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Optometric Association     Volume:  57     ISSN:  0003-0244     ISO Abbreviation:  J Am Optom Assoc     Publication Date:  1986 May 
Date Detail:
Created Date:  1986-07-07     Completed Date:  1986-07-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7505575     Medline TA:  J Am Optom Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  382-9     Citation Subset:  IM    
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MeSH Terms
Analysis of Variance
Blood Pressure / drug effects*
Child, Preschool
Diabetes Mellitus / physiopathology
Double-Blind Method
Middle Aged
Ophthalmic Solutions
Phenylephrine / pharmacology*
Prospective Studies
Pulse / drug effects*
Pyridines / pharmacology*
Tropicamide / pharmacology*
Reg. No./Substance:
0/Ophthalmic Solutions; 0/Pyridines; 1508-75-4/Tropicamide; 59-42-7/Phenylephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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