Document Detail

The effect of a toothpaste containing 2% zinc citrate and 0.3% Triclosan on bacterial viability and plaque growth in vivo compared to a toothpaste containing 0.3% Triclosan and 2% copolymer.
MedLine Citation:
PMID:  14725385     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare the antimicrobial efficacy and effect on plaque growth of a new silica-based fluoride toothpaste containing 2% zinc citrate/ 0.3% Triclosan with a silica-based fluoride toothpaste containing 0.3% Triclosan/2% copolymer. METHODS: In Study 1, plaque was collected after one week's use of each toothpaste and assessed for bacterial viability, live/ dead ratio and microbial membrane integrity. In study 2, plaque was measured immediately and 18 hours after a single brushing with the specified toothpastes. RESULTS: The 2% zinc citrate/0.3% Triclosan formulation significantly reduced the total number of viable aerobic and anaerobic bacteria (p = 0.0223 and p = 0.0443 respectively) compared to the 0.3% Triclosan/2% copolymer formulation. Both toothpastes increased the bacterial membrane permeability significantly. However, the proportion of live bacteria for the 2% zinc citrate/0.3% Triclosan product was significantly reduced (p < 0.05). Study 2 showed significantly less plaque growth 18 hours after using the 2% zinc citrate/0.3% Triclosan toothpaste compared to the 0.3% Triclosan/2% copolymer toothpaste (p < 0.01). CONCLUSION: Regular use of a fluoride toothpaste containing 2% zinc citrate and 0.3% Triclosan, significantly reduced the viability of plaque bacteria compared to a fluoride toothpaste containing 0.3% Triclosan/ 2% copolymer 12 hours after brushing. In addition, a clinical plaque growth study confirmed that this anti-microbial efficacy leads to a significant reduction in plaque growth.
S E Adams; A J Theobald; N M Jones; M G Brading; T F Cox; A Mendez; D M Chesters; D G Gillam; C Hall; J Holt
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  International dental journal     Volume:  53     ISSN:  0020-6539     ISO Abbreviation:  Int Dent J     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-16     Completed Date:  2004-02-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374714     Medline TA:  Int Dent J     Country:  England    
Other Details:
Languages:  eng     Pagination:  398-403     Citation Subset:  D; IM    
Unilever Oral Care, Quarry Road East, Bebington, Wirral, UK.
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MeSH Terms
Analysis of Variance
Anti-Infective Agents, Local / administration & dosage,  therapeutic use
Bacteria / drug effects*,  growth & development
Bacteria, Aerobic / drug effects,  growth & development
Bacteria, Anaerobic / drug effects,  growth & development
Cariostatic Agents / therapeutic use
Citric Acid / administration & dosage,  therapeutic use*
Colony Count, Microbial
Cross-Over Studies
Dental Plaque / microbiology*,  physiopathology
Double-Blind Method
Fluorides / therapeutic use
Time Factors
Toothpaste / therapeutic use*
Triclosan / administration & dosage,  therapeutic use*
Zinc / administration & dosage,  therapeutic use*
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Cariostatic Agents; 0/Fluorides; 0/Toothpaste; 3380-34-5/Triclosan; 7440-66-6/Zinc; 77-92-9/Citric Acid

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