| The effect of titanium dioxide on the biochemical constituents of the brain of Zebrafish (Danio rerio): An FT-IR study. | |
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MedLine Citation:
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PMID: 21420897 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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During recent years, the use of nanoparticles (NPs) in commercial products and industrial applications has increased greatly. One of the most widely used nanoparticles is titanium dioxide (nTiO(2)). It is a very versatile compound that has many uses, depending on its particle size. In the present paper an attempt is made to study the effect of TiO(2) nanoparticles and its bulk material on the biochemical constituents of the brain of Zebrafish (Danio rerio) by using FT-IR technique. FT-IR spectra reveals significant differences in absorbance intensities between the control and TiO(2) exposed brain tissues, reflecting alterations on the major biochemical constituents such as proteins, lipids and nucleic acids in the brain tissues of D. rerio due to TiO(2) exposure. The results further reveal that TiO(2) nanoparticles are more toxic than their bulk counterparts. The higher ratio of integrated area of carbonyl-to-CH(2) peaks (1743cm(-1):1458cm(-1)) observed in the present study in the nTiO(2) exposed brain tissues suggests that lipids are being oxidized. Since oxidation can cause an increase in carbonyls and a degradation of lipids, both of these changes could be contributed to the elevated ratio. Further, the observed decreasing ratio of integrated areas of both 1458cm(-1):1542cm(-1) and 1743cm(-1):1542cm(-1) in the TiO(2) exposed tissues suggests that lipid degradation predominates over carbonyl formation. The observed changes in the biochemical constituents in the brain tissues of D. rerio could be due to the overproduction of ROS. |
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Authors:
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Pl Rm Palaniappan; K S Pramod |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-23 |
Journal Detail:
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Title: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Volume: - ISSN: 1873-3557 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602533 Medline TA: Spectrochim Acta A Mol Biomol Spectrosc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Physics, Annamalai University, Annamalai Nagar-608002 (Res: 48 - Tobacco Garden, Therku Iruppu, Annamalai Nagar), India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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