Document Detail

The effect of tissue elastic properties and surfactant on alveolar stability.
MedLine Citation:
PMID:  20724566     Owner:  NLM     Status:  MEDLINE    
This paper presents a novel mathematical model of alveoli, which simulates the effects of tissue elasticity and surfactant on the stability of human alveoli. The model incorporates a spherical approximation to the alveolar geometry, the hysteretic behavior of pulmonary surfactant and tissue elasticity. The model shows that the alveolus without surfactant and the elastic properties of the lung tissue are always at an unstable equilibrium, with the capability both to collapse irreversibly and to open with infinite volume when the alveolus has small opening radii. During normal tidal breathing, the alveolus can becomes stable, if surfactant is added. Including the passive effect of tissue elasticity stabilizes the alveolus, further allowing the alveoli to be stable, even for lung volumes below residual volume. The model is the first to describe the combined effects of tissue elasticity and surfactant on alveolar stability. The model may be used as an integrated part of a more comprehensive model of the respiratory system, since it can predict opening pressures of alveoli.
Steen Andreassen; Kristoffer L Steimle; Mads L Mogensen; Jorge Bernardino de la Serna; Stephen Rees; Dan S Karbing
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-19
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  109     ISSN:  1522-1601     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-09     Completed Date:  2011-02-18     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1369-77     Citation Subset:  IM    
Center for Model-Based Medical Decision Support, Aalborg University, Aalborg, Denmark.
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MeSH Terms
Computer Simulation
Elastic Tissue / anatomy & histology,  physiology*
Lung Compliance
Lung Volume Measurements
Models, Biological*
Organ Size
Pulmonary Alveoli / anatomy & histology,  physiology*
Pulmonary Surfactant-Associated Proteins / physiology*
Residual Volume
Respiratory Mechanics
Respiratory Physiological Phenomena*
Surface Tension
Reg. No./Substance:
0/Pulmonary Surfactant-Associated Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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