Document Detail

The effect of time and of vasoactive drugs on capillary leakage induced during myocardial contrast echocardiography.
MedLine Citation:
PMID:  14961790     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Premature ventricular contractions (PVC), capillary leakage, and petechial hemorrhage can occur during myocardial contrast echocardiography (MCE). The effects occur as a result of the interaction of contrast agent microbubbles and the ultrasound, but the detailed etiology of the effects is not yet clear. This study tested the hypothesis that the capillary leakage results from a physiological response to injury, which might be protracted and modulated by vasoactive drugs. METHODS: Hairless rats were anesthetized and transthoracically scanned with a diagnostic ultrasound system (GE Vingmed System V) at 1.7 MHz with 1:4 triggered frames at end systole. The scan head and rats were mounted in a 37 degrees C water bath to assure free-field conditions and placement of the heart at a similar focal distance as humans. A tail vein was cannulated for injections of Optison contrast agent, vasoactive medications, and Evans Blue dye (EB). EB was injected as a marker of capillary leakage before or after scanning. RESULTS: PVCs, petechia, and capillary leakage occurred during ultrasound exposure of microbubbles in myocardium, with no effects detected in shams. The influence of the vasoactive medications propranolol and isoproterenol on the effects did not support the hypothesis. Capillary leakage occurred during and postexposure, but diminished for EB injection 20 minutes after scanning with or without isoproterenol pretreatment. CONCLUSION: MCE induced PVCs, petechia, and capillary leakage, all of which ended immediately or within 20 minutes after the examination. Contrary to the hypothesis of a physiological mechanism, the capillary leakage appears to be primarily a mechanical effect rather than a physiological response.
Douglas Miller; Peng Li; William F Armstrong
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Echocardiography (Mount Kisco, N.Y.)     Volume:  21     ISSN:  0742-2822     ISO Abbreviation:  Echocardiography     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-13     Completed Date:  2004-05-26     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8511187     Medline TA:  Echocardiography     Country:  United States    
Other Details:
Languages:  eng     Pagination:  125-32     Citation Subset:  IM    
Department of Radiology, University of Michigan Department of Cardiology, University of Michigan, Ann Arbor, Michigan 48109-0553, USA.
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MeSH Terms
Bronchodilator Agents / pharmacology
Capillary Fragility / drug effects*,  physiology*
Coloring Agents / diagnostic use
Contrast Media / adverse effects*
Echocardiography / adverse effects,  methods*
Evans Blue / diagnostic use
Isoproterenol / pharmacology
Microbubbles / adverse effects
Propranolol / pharmacology
Purpura / etiology
Sodium Chloride / administration & dosage
Time Factors
Vasodilator Agents / pharmacology*
Ventricular Premature Complexes / etiology
Reg. No./Substance:
0/Bronchodilator Agents; 0/Coloring Agents; 0/Contrast Media; 0/Vasodilator Agents; 314-13-6/Evans Blue; 525-66-6/Propranolol; 7647-14-5/Sodium Chloride; 7683-59-2/Isoproterenol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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