| The effect of time and of vasoactive drugs on capillary leakage induced during myocardial contrast echocardiography. | |
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MedLine Citation:
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PMID: 14961790 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Premature ventricular contractions (PVC), capillary leakage, and petechial hemorrhage can occur during myocardial contrast echocardiography (MCE). The effects occur as a result of the interaction of contrast agent microbubbles and the ultrasound, but the detailed etiology of the effects is not yet clear. This study tested the hypothesis that the capillary leakage results from a physiological response to injury, which might be protracted and modulated by vasoactive drugs. METHODS: Hairless rats were anesthetized and transthoracically scanned with a diagnostic ultrasound system (GE Vingmed System V) at 1.7 MHz with 1:4 triggered frames at end systole. The scan head and rats were mounted in a 37 degrees C water bath to assure free-field conditions and placement of the heart at a similar focal distance as humans. A tail vein was cannulated for injections of Optison contrast agent, vasoactive medications, and Evans Blue dye (EB). EB was injected as a marker of capillary leakage before or after scanning. RESULTS: PVCs, petechia, and capillary leakage occurred during ultrasound exposure of microbubbles in myocardium, with no effects detected in shams. The influence of the vasoactive medications propranolol and isoproterenol on the effects did not support the hypothesis. Capillary leakage occurred during and postexposure, but diminished for EB injection 20 minutes after scanning with or without isoproterenol pretreatment. CONCLUSION: MCE induced PVCs, petechia, and capillary leakage, all of which ended immediately or within 20 minutes after the examination. Contrary to the hypothesis of a physiological mechanism, the capillary leakage appears to be primarily a mechanical effect rather than a physiological response. |
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Authors:
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Douglas Miller; Peng Li; William F Armstrong |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Echocardiography (Mount Kisco, N.Y.) Volume: 21 ISSN: 0742-2822 ISO Abbreviation: Echocardiography Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-02-13 Completed Date: 2004-05-26 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8511187 Medline TA: Echocardiography Country: United States |
Other Details:
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Languages: eng Pagination: 125-32 Citation Subset: IM |
Affiliation:
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Department of Radiology, University of Michigan Department of Cardiology, University of Michigan, Ann Arbor, Michigan 48109-0553, USA. douglm@umich.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bronchodilator Agents / pharmacology Capillary Fragility / drug effects*, physiology* Coloring Agents / diagnostic use Contrast Media / adverse effects* Echocardiography / adverse effects, methods* Evans Blue / diagnostic use Isoproterenol / pharmacology Microbubbles / adverse effects Propranolol / pharmacology Purpura / etiology Rats Sodium Chloride / administration & dosage Time Factors Vasodilator Agents / pharmacology* Ventricular Premature Complexes / etiology |
| Chemical | |
Reg. No./Substance:
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0/Bronchodilator Agents; 0/Coloring Agents; 0/Contrast Media; 0/Vasodilator Agents; 314-13-6/Evans Blue; 525-66-6/Propranolol; 7647-14-5/Sodium Chloride; 7683-59-2/Isoproterenol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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