Document Detail

The effect of insemination/injection time on the results of IVF and ICSI.
MedLine Citation:
PMID:  11473969     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to investigate whether a pre-incubation time between oocyte retrieval and insemination or injection had any effect on the success rate of IVF or intracytoplasmic sperm injection (ICSI). Based on previously published data, many laboratories retain a time interval of several hours between oocyte retrieval and insemination/injection. In our setting, insemination and injection times are dependent only on the laboratory workload. METHODS: Totals of 881 IVF and 432 ICSI cycles performed between 1997 and 1999 were analysed retrospectively. Oocyte retrieval occurred 36 h after human chorionic gonadotrophin administration, and insemination or injection took place 1--7 or 0.5--8 h after oocyte retrieval respectively. RESULTS: No statistically significant differences were found between these time periods and outcome of IVF and ICSI with respect to fertilization rate, embryo quality, implantation rate, abortion and ongoing pregnancy rates, except for the abortion rate after IVF. As this finding may be due to chance and no differences were found in the ongoing pregnancy rates, this finding was considered to be of less importance. CONCLUSIONS: If laboratory control and efficiency demands early insemination or injection, it could be performed without reservation.
M Jacobs; A M Stolwijk; A M Wetzels
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  16     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-27     Completed Date:  2001-10-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  1708-13     Citation Subset:  IM    
Fertility Laboratory, Department of Obstetrics and Gynaecology, University Medical Center Nijmegen, Nijmegen, The Netherlands.
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MeSH Terms
Abortion, Spontaneous
Embryo Implantation
Embryo Transfer
Embryo, Mammalian / physiology
Fertilization in Vitro*
Logistic Models
Oocytes / physiology*
Sperm Injections, Intracytoplasmic*
Time Factors
Tissue and Organ Harvesting
Treatment Outcome*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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