Document Detail


The effect of tegaserod on esophageal submucosal glands bicarbonate and mucin secretion.
MedLine Citation:
PMID:  18270837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tegaserod, a 5-HT4 partial agonist, was shown to reduce esophageal acid exposure in patients with gastroesophageal reflux disease; however, its mechanism of action is poorly understood. Therefore, we have examined the effect of tegaserod on luminal bicarbonate and mucin secretion in the isolated perfused pig esophagus. We also studied its role in esophageal protection using SMG-bearing pig esophagus in comparison to the rabbit esophagus, which is devoid of them. The tissues were mounted in Ussing chambers, and acid injury was replicated by exposing the lumen to acid (pH 1.6) or acid/pepsin (pH 2.5). In pig esophagus, tegaserod increased bicarbonate secretion, but had no effect on basal mucin secretion. In Ussing chambers, tegaserod reduced injury to pig, but not rabbit esophagus exposed to acid (pH 2.5) plus pepsin. These results indicate that tegaserod stimulates SMG bicarbonate secretion, an effect that likely accounts for the observed protection against acid-pepsin injury to pig, but not rabbit, esophagus.
Authors:
Solange Abdulnour-Nakhoul; Nelia A Tobey; Nazih L Nakhoul; Scott A Wheeler; Ximena Vanegas; Roy C Orlando
Related Documents :
6432877 - Arachidonate 5-lipoxygenase and its new inhibitors.
1388207 - Non-prostanoid thromboxane a2 receptor antagonists with a dibenzoxepin ring system. 1.
1975837 - Excitatory amino acid-induced formation of inositol phosphates in guinea-pig cerebral c...
7766387 - 15-hydroperoxydehydroabietic acid--a contact allergen in colophony from pinus species.
7320697 - Lysosomal abnormalities in hadacidin-treated dictyostelium discoideum amoebae.
22039047 - Identification and mechanism of 10-carbon fatty acid as modulating ligand of peroxisome...
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-02-13
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  53     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-20     Completed Date:  2008-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2366-72     Citation Subset:  AIM; IM    
Affiliation:
Southeast Louisiana Veterans Health Care Network, and Departments of Medicine and Physiology, Tulane University School of Medicine, c/o Tulane Medical Center, 1430 Tulane Avenue, New Orleans, LA 70112-2699, USA. solange@tulane.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Bicarbonates / metabolism*
Esophagus / drug effects,  secretion*
Hydrochloric Acid / pharmacology
Indoles / pharmacology*
Male
Mucins / secretion*
Mucous Membrane / drug effects,  secretion
Pepsin A / pharmacology
Rabbits
Serotonin Agonists / pharmacology*
Swine
Grant Support
ID/Acronym/Agency:
DK 036013/DK/NIDDK NIH HHS; DK 62295-01A1/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Bicarbonates; 0/Indoles; 0/Mucins; 0/Serotonin Agonists; 145158-71-0/tegaserod; 7647-01-0/Hydrochloric Acid; EC 3.4.23.1/Pepsin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A meta-analysis on the efficacy of probiotics for maintenance of remission and prevention of clinica...
Next Document:  The expression of Msi-1 and its significance in small intestinal mucosa severely damaged by high-dos...