Document Detail

The effect of tegaserod on esophageal submucosal glands bicarbonate and mucin secretion.
MedLine Citation:
PMID:  18270837     Owner:  NLM     Status:  MEDLINE    
Tegaserod, a 5-HT4 partial agonist, was shown to reduce esophageal acid exposure in patients with gastroesophageal reflux disease; however, its mechanism of action is poorly understood. Therefore, we have examined the effect of tegaserod on luminal bicarbonate and mucin secretion in the isolated perfused pig esophagus. We also studied its role in esophageal protection using SMG-bearing pig esophagus in comparison to the rabbit esophagus, which is devoid of them. The tissues were mounted in Ussing chambers, and acid injury was replicated by exposing the lumen to acid (pH 1.6) or acid/pepsin (pH 2.5). In pig esophagus, tegaserod increased bicarbonate secretion, but had no effect on basal mucin secretion. In Ussing chambers, tegaserod reduced injury to pig, but not rabbit esophagus exposed to acid (pH 2.5) plus pepsin. These results indicate that tegaserod stimulates SMG bicarbonate secretion, an effect that likely accounts for the observed protection against acid-pepsin injury to pig, but not rabbit, esophagus.
Solange Abdulnour-Nakhoul; Nelia A Tobey; Nazih L Nakhoul; Scott A Wheeler; Ximena Vanegas; Roy C Orlando
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Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-02-13
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  53     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-20     Completed Date:  2008-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2366-72     Citation Subset:  AIM; IM    
Southeast Louisiana Veterans Health Care Network, and Departments of Medicine and Physiology, Tulane University School of Medicine, c/o Tulane Medical Center, 1430 Tulane Avenue, New Orleans, LA 70112-2699, USA.
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MeSH Terms
Bicarbonates / metabolism*
Esophagus / drug effects,  secretion*
Hydrochloric Acid / pharmacology
Indoles / pharmacology*
Mucins / secretion*
Mucous Membrane / drug effects,  secretion
Pepsin A / pharmacology
Serotonin Agonists / pharmacology*
Grant Support
Reg. No./Substance:
0/Bicarbonates; 0/Indoles; 0/Mucins; 0/Serotonin Agonists; 145158-71-0/tegaserod; 7647-01-0/Hydrochloric Acid; EC A

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