| The effect of taurine on the salt-dependent blood pressure increase in the voltage-dependent calcium channel beta 3-subunit-deficient mouse. | |
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MedLine Citation:
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PMID: 12688409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine the anti-hypertensive effect of taurine, we studied the effects of taurine on the salt-dependent blood pressure elevation, the electrocardiogram, and plasma catecholamine levels in the voltage-dependent calcium channel beta3-subunit-deficient mouse. In the wild-type mice, chronic high-salt loading (8% NaCl in chow) did not increase the blood pressure, whereas there was a significant increase in the systolic blood pressure in the beta3-subunit-deficient mice given a high-salt diet. Oral supplementation of taurine (3% in drinking water) could attenuate the increase in the blood pressure elicited by the high-salt diet. Plasma catecholamine levels were significantly decreased by the high-salt diet, and supplementation of taurine prevented those decreases in beta3-subunit-deficient mice. It is suggested, therefore, that chronic supplementation of taurine has an anti-hypertensive action in salt-dependent blood pressure elevation. |
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Authors:
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Kunie Hagiwara; Gorou Kuroki; Pei Xiang Yuan; Takashi Suzuki; Manabu Murakami; Takuzou Hano; Hironobu Sasano; Teruyuki Yanagisawa |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular pharmacology Volume: 41 Suppl 1 ISSN: 0160-2446 ISO Abbreviation: J. Cardiovasc. Pharmacol. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2003-04-11 Completed Date: 2003-06-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7902492 Medline TA: J Cardiovasc Pharmacol Country: United States |
Other Details:
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Languages: eng Pagination: S127-31 Citation Subset: IM |
Affiliation:
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Department of Molecular Pharmacology, Tohoku University School of Medicine, Sendai, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects*, physiology Calcium Channels / deficiency*, genetics Epinephrine / blood Heart Rate / drug effects, physiology Mice Mice, Knockout Norepinephrine / blood Sodium Chloride, Dietary / pharmacology* Taurine / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channels; 0/Sodium Chloride, Dietary; 107-35-7/Taurine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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