Document Detail


The effect of taurine on the salt-dependent blood pressure increase in the voltage-dependent calcium channel beta 3-subunit-deficient mouse.
MedLine Citation:
PMID:  12688409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To examine the anti-hypertensive effect of taurine, we studied the effects of taurine on the salt-dependent blood pressure elevation, the electrocardiogram, and plasma catecholamine levels in the voltage-dependent calcium channel beta3-subunit-deficient mouse. In the wild-type mice, chronic high-salt loading (8% NaCl in chow) did not increase the blood pressure, whereas there was a significant increase in the systolic blood pressure in the beta3-subunit-deficient mice given a high-salt diet. Oral supplementation of taurine (3% in drinking water) could attenuate the increase in the blood pressure elicited by the high-salt diet. Plasma catecholamine levels were significantly decreased by the high-salt diet, and supplementation of taurine prevented those decreases in beta3-subunit-deficient mice. It is suggested, therefore, that chronic supplementation of taurine has an anti-hypertensive action in salt-dependent blood pressure elevation.
Authors:
Kunie Hagiwara; Gorou Kuroki; Pei Xiang Yuan; Takashi Suzuki; Manabu Murakami; Takuzou Hano; Hironobu Sasano; Teruyuki Yanagisawa
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  41 Suppl 1     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-04-11     Completed Date:  2003-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S127-31     Citation Subset:  IM    
Affiliation:
Department of Molecular Pharmacology, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*,  physiology
Calcium Channels / deficiency*,  genetics
Epinephrine / blood
Heart Rate / drug effects,  physiology
Mice
Mice, Knockout
Norepinephrine / blood
Sodium Chloride, Dietary / pharmacology*
Taurine / pharmacology*
Chemical
Reg. No./Substance:
0/Calcium Channels; 0/Sodium Chloride, Dietary; 107-35-7/Taurine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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