| The effect of taurine on mesenteric blood flow and organ injury in sepsis. | |
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MedLine Citation:
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PMID: 18163178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endotoxin decreases mesenteric blood flow and inflicts organ injury via free radicals. We investigated whether taurine, an endogenous antioxidant and vasodilator, could attenuate the deleterious effects of endotoxin in a mouse model of sepsis. Swiss albino mice were allocated into four groups and treated either with taurine (150 mg/kg, i.p. at 0(th), 8(th), 16(th) h) or its solvent sterile saline (NaCl 0.9%, w/v) while E. coli endotoxin (20 mg/kg, i.p.) or its solvent saline were also given at 8(th) h. At 24(th) h the animals were anaesthetized and the mesenteric blood flow was measured by using perivascular ultrasonic Doppler-flowmeter. The animals were then exsanguinated, the spleen, liver, and kidneys were isolated for histopathological examination. Thiobarbituric acid-reacting substances (TBARS), glutathione, and myeloperoxidase activity were determined in the liver samples. Endotoxin significantly decreased the mesenteric blood flow and glutathione levels in liver while TBARS and myeloperoxidase activity were increased. However, taurine did not block the deleterious effects of endotoxin nor it did attenuate the histopathological injury. Therefore, we concluded that endotoxin-induced organ injury via free radicals is resistant to blockade by taurine. |
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Authors:
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A Erdem; A M Sevgili; F Akbiyik; P Atilla; N Cakar; Z D Balkanci; A B Iskit; M O Guc |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-12-28 |
Journal Detail:
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Title: Amino acids Volume: 35 ISSN: 1438-2199 ISO Abbreviation: Amino Acids Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-08-15 Completed Date: 2008-10-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200312 Medline TA: Amino Acids Country: Austria |
Other Details:
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Languages: eng Pagination: 403-10 Citation Subset: IM |
Affiliation:
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Department of Physiology, Faculty of Medicine, Hacettepe University, Ankara, Turkey. aerdem@hacettepe.edu.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Flow Velocity / drug effects* Disease Models, Animal Endotoxins / antagonists & inhibitors, toxicity Free Radicals / metabolism Glutathione / analysis Injections, Intraperitoneal Mesentery / blood supply, drug effects* Mice Multiple Organ Failure / pathology, physiopathology* Peroxidase / analysis, metabolism Sepsis / drug therapy, pathology, physiopathology* Taurine / pharmacology* Thiobarbituric Acid Reactive Substances / metabolism Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Endotoxins; 0/Free Radicals; 0/Thiobarbituric Acid Reactive Substances; 107-35-7/Taurine; 70-18-8/Glutathione; EC 1.11.1.7/Peroxidase |
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