Document Detail


The effect of tacrolimus (FK-506) on Japanese patients with refractory Crohn's disease.
MedLine Citation:
PMID:  18958546     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Recent evidence indicates that intravenous or oral therapy with tacrolimus (FK-506) is effective in treating patients with Crohn's disease. We evaluated the usefulness of tacrolimus therapy for Japanese patients with refractory Crohn's disease. METHODS: Fourteen adult Japanese patients with Crohn's disease that was refractory to conventional therapies, including prednisolone (n = 5), azathioprine (n = 6), and infliximab (n = 5), were enrolled. Treatment with tacrolimus was started orally or intravenously and aimed for serum trough levels of 10-15 ng/ml. After the patients achieved clinical improvement, tacrolimus maintenance therapy was administered to maintain the trough level at 5-10 ng/ml. RESULTS: All patients achieved remission or significant improvement 40 days after starting tacrolimus treatment. By 120 days after the start of therapy, 9 (64%) patients achieved remission, 2 patients (14%) achieved significant improvement, and only 3 patients (21%) relapsed. The relapsed patients were treated with infliximab therapy and achieved remission. Steroids were discontinued by the 5 patients who had taken steroids before the study began. Adverse effects of tacrolimus included a temporary increase in serum creatinine concentration (n = 1, 7%), hyperkalemia (n = 1, 7%), and tremor (n = 1, 7%). CONCLUSIONS: Tacrolimus therapy is effective and well tolerated in patients with Crohn's disease that is refractory to conventional therapies.
Authors:
Hiroyuki Tamaki; Hiroshi Nakase; Minoru Matsuura; Satoko Inoue; Sakae Mikami; Satoru Ueno; Norimitsu Uza; Hiroshi Kitamura; Katsuhiro Kasahara; Tsutomu Chiba
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-29
Journal Detail:
Title:  Journal of gastroenterology     Volume:  43     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-29     Completed Date:  2009-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  774-9     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology & Hepatology, Graduate School of Medicine, Kyoto University, 54 Kawara, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Asian Continental Ancestry Group
Cohort Studies
Crohn Disease / drug therapy*,  ethnology,  prevention & control
Drug Administration Schedule
Female
Glucocorticoids / administration & dosage
Humans
Immunosuppressive Agents / administration & dosage,  therapeutic use*
Japan
Male
Middle Aged
Recurrence / prevention & control
Retrospective Studies
Tacrolimus / administration & dosage,  therapeutic use*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Immunosuppressive Agents; 109581-93-3/Tacrolimus

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