Document Detail


The effect of systemic lupus erythematosus and long-term steroid therapy on bone mass in pre-menopausal women.
MedLine Citation:
PMID:  7551659     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of our study was to assess bone mineral density (BMD) in pre-menopausal women with systemic lupus erythematosus (SLE) and the influence of disease activity and use of corticosteroids. Lumbar and femoral BMD were measured in 43 patients with SLE (28 on regular steroid therapy, 15 with recent onset, non-treated) and compared with 43 healthy women matched for age. In addition, 21 SLE patients treated with corticosteroids were followed-up with a mean of 36.6 +/- 12.7 months. BMD was significantly lower in SLE patients with prednisone doses > or = 7.5 mg/day than those of recent onset (lumbar: 1.07 +/- 0.11 vs 1.15 +/- 0.13, P = 0.039; femur: 0.85 +/- 0.13 vs 0.98 +/- 0.21, P = 0.034) and the control group (lumbar: 1.07 +/- 0.11 vs 1.13 +/- 0.10, P = 0.040; femur: 0.85 +/- 0.13 vs 0.93 +/- 0.10, P = 0.028). In addition, 18% of SLE steroid users had osteoporosis. Lumbar and femoral BMD were inversely correlated with the time of treatment and the cumulative doses of prednisone. There were no significant BMD changes during the 3-yr follow-up period. In conclusion, in SLE pre-menopausal patients lumbar and femoral BMD is decreased and related to long-term corticosteroid therapy.
Authors:
F Pons; P Peris; N Guañabens; J Font; M Huguet; G Espinosa; M Ingelmo; J Muñoz-Gomez; J Setoain
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of rheumatology     Volume:  34     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-11-07     Completed Date:  1995-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  742-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Nuclear Medicine, Hospital Clínic i Provincial, University of Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bone Density / drug effects*
Cross-Sectional Studies
Dose-Response Relationship, Drug
Female
Femur / metabolism
Follow-Up Studies
Humans
Lumbar Vertebrae / metabolism
Lupus Erythematosus, Systemic / drug therapy*,  metabolism*
Osteoporosis / chemically induced
Prednisone / administration & dosage,  adverse effects*,  therapeutic use
Premenopause*
Reference Values
Time Factors
Chemical
Reg. No./Substance:
53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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