Document Detail

The effect of systemic lupus erythematosus and long-term steroid therapy on bone mass in pre-menopausal women.
MedLine Citation:
PMID:  7551659     Owner:  NLM     Status:  MEDLINE    
The aim of our study was to assess bone mineral density (BMD) in pre-menopausal women with systemic lupus erythematosus (SLE) and the influence of disease activity and use of corticosteroids. Lumbar and femoral BMD were measured in 43 patients with SLE (28 on regular steroid therapy, 15 with recent onset, non-treated) and compared with 43 healthy women matched for age. In addition, 21 SLE patients treated with corticosteroids were followed-up with a mean of 36.6 +/- 12.7 months. BMD was significantly lower in SLE patients with prednisone doses > or = 7.5 mg/day than those of recent onset (lumbar: 1.07 +/- 0.11 vs 1.15 +/- 0.13, P = 0.039; femur: 0.85 +/- 0.13 vs 0.98 +/- 0.21, P = 0.034) and the control group (lumbar: 1.07 +/- 0.11 vs 1.13 +/- 0.10, P = 0.040; femur: 0.85 +/- 0.13 vs 0.93 +/- 0.10, P = 0.028). In addition, 18% of SLE steroid users had osteoporosis. Lumbar and femoral BMD were inversely correlated with the time of treatment and the cumulative doses of prednisone. There were no significant BMD changes during the 3-yr follow-up period. In conclusion, in SLE pre-menopausal patients lumbar and femoral BMD is decreased and related to long-term corticosteroid therapy.
F Pons; P Peris; N Guañabens; J Font; M Huguet; G Espinosa; M Ingelmo; J Muñoz-Gomez; J Setoain
Related Documents :
9660389 - Increased bone resorption during the first year after stroke.
10395249 - Bone metabolism after human parturition and the effect of lactation: longitudinal analy...
10076939 - Effects of glucocorticoids on bone mineral density in rheumatoid arthritis patients. a ...
9116389 - The increase in spinal bone density that occurs in response to fluoride therapy for ost...
18044089 - Full length parathyroid hormone (1-84) in the treatment of osteoporosis in postmenopaus...
23672989 - Role of preablation neutrophil/lymphocyte ratio on outcomes of cryoballoon-based atria...
25163949 - Accuracy of preoperative templating in total hip arthroplasty.
24765899 - Effects of single shot femoral nerve block combined with intrathecal morphine for posto...
17043539 - Can a nurse-directed intervention reduce the exposure of patients with knee osteoarthri...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of rheumatology     Volume:  34     ISSN:  0263-7103     ISO Abbreviation:  Br. J. Rheumatol.     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-11-07     Completed Date:  1995-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302415     Medline TA:  Br J Rheumatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  742-6     Citation Subset:  AIM; IM    
Department of Nuclear Medicine, Hospital Clínic i Provincial, University of Barcelona, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bone Density / drug effects*
Cross-Sectional Studies
Dose-Response Relationship, Drug
Femur / metabolism
Follow-Up Studies
Lumbar Vertebrae / metabolism
Lupus Erythematosus, Systemic / drug therapy*,  metabolism*
Osteoporosis / chemically induced
Prednisone / administration & dosage,  adverse effects*,  therapeutic use
Reference Values
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Menstrual disorders in girls with systemic lupus erythematosus treated with cyclophosphamide.
Next Document:  Effect of methotrexate alone or in combination with sulphasalazine on the production and circulating...