Document Detail


The effect of the synthetic prostaglandin analog 15 (R) 15 methyl-PGE2 methyl ester on gastric mucosal hemorrhage induced in rats by taurocholic acid and hydrochloric acid.
MedLine Citation:
PMID:  300988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incidence of mucosal hemorrhage induced in rats by the oral administration of taurocholic acid (TCA) and hydrochloric acid (HCl) both singly and in combination was investigated. The effect of prostaglandin 15 (R) 15 methyl-PGE2 methyl ester (Me-PGE2) on the occurrence of hemorrhage induced by TCA with HCl was also studied. The incidence of hemorrhage induced by TCA (10 mM) alone and HCl (160 mM) alone was minimal and not different from that induced by the control solution. The combination of TCA (10 mM) and HCl (160 mM) produced bleeding in 67.7% of animals. The addition of 15 (R) 15 methyl-PGE2 methyl ester (9.9 micronM, corresponding to 50 microng/Kg) significantly reduced the incidence of hemorrhage induced by the combination of TCA with HCl from 67.7% to 31.3%. This suggests that this synthetic prostaglandin may be of value in conditions thought to be associated with reflux of bile into the stomach.
Authors:
H A Carmichael; L Nelson; R I Russell; A Lyon; V Chandra
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of digestive diseases     Volume:  22     ISSN:  0002-9211     ISO Abbreviation:  Am J Dig Dis     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-06-22     Completed Date:  1977-06-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0404011     Medline TA:  Am J Dig Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  411-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Antagonism
Gastric Mucosa / drug effects*
Gastrointestinal Hemorrhage / chemically induced,  drug therapy
Hydrochloric Acid / antagonists & inhibitors
Male
Prostaglandins E / pharmacology*,  therapeutic use
Prostaglandins, Synthetic
Rats
Taurocholic Acid / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Prostaglandins E; 0/Prostaglandins, Synthetic; 7647-01-0/Hydrochloric Acid; 81-24-3/Taurocholic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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