Document Detail


The effect of synthetic fragment 31-44 of human growth hormone on glucose uptake by isolated adipose tissue.
MedLine Citation:
PMID:  6838555     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Synthetic tetradecapeptide corresponding to amino acid sequence 31-44 of human growth hormone molecule and possessing a lipotropic activity was tested for the ability to stimulate glucose uptake by isolated epididymal fat pads of fed rats. Tetradecapeptide 31-44 (1 microgram/ml), growth hormone (1 microgram/ml) and insulin (50 microU/ml) stimulated in about equal degree the uptake of [U-14C]glucose by adipose tissue. Tissue samples were preliminary incubated for 3-4 hours in the absence of hormones to eliminate the refractoriness to the insulin-like effects of growth hormone. Without preincubation the tissue was refractory to the action of growth hormone and tetradecapeptide 31-44, but was sensitive to insulin. The data obtained together with the findings of Lewis et al., which showed that 20K structural variant of human growth hormone having the deletion of residues 32-46 cannot stimulate glucose uptake and lipolysis in rats, make it possible to suggest that both activities are associated with fragment 31-44.
Authors:
N A Yudaev; Pankov YuA; Keda YuM; E T Sazina; T A Osipova; Shwachkin YuP; M N Ryabtsev
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  110     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  866-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / drug effects,  metabolism*
Animals
Biological Transport, Active / drug effects
Carbon Radioisotopes / diagnostic use
Glucose / metabolism*
Growth Hormone / chemical synthesis,  pharmacology*
Humans
Kinetics
Male
Peptide Fragments / chemical synthesis,  pharmacology*
Rats
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Peptide Fragments; 0/somatotropin (31-44); 50-99-7/Glucose; 9002-72-6/Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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