| The effect of sympathetic stimulation on proximal brachial artery mechanics in humans--differential behaviour within the length of the brachial artery? | |
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MedLine Citation:
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PMID: 15329053 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The mechanical properties of arteries play a major role in the regulation of blood pressure and cardiac performance. The effect of sympathetic stimulation on the mechanical properties of the proximal brachial artery was analysed in 18 healthy volunteers, nine young (25 +/- 2 years) and nine elderly (69 +/- 2 years). METHODS: A non-invasive ultrasonic echo-tracking system for measurement of systolic/diastolic variation of the proximal brachial artery diameter in combination with intra-arterial pressure measurements was used to determine wall mechanics. The pressure-diameter (P-D) relationship, distensibility coefficient (DC), compliance coefficient (CC) and stiffness(beta) were obtained at rest and during sympathetic stimulation induced by lower body negative pressure (LBNP). RESULTS: The peripheral vascular resistance increased by 100 and 72%, respectively in the young and elderly during LBNP (P < 0.001). Simultaneously, the mechanical properties of the proximal brachial artery remained unaltered, as estimated from both P-D relationship and stiffness in young (beta-index rest: 5.2 +/- 0.9, LBNP: 5.5 +/- 1.3, NS) as well as elderly (beta-index rest: 13.6 +/- 4.6, LBNP: 16.1 +/- 4.7, NS). CONCLUSIONS: LBNP-induced sympathetic activation does not change proximal brachial artery mechanics, in contrast to earlier reports on the muscular distal brachial artery. This may imply that the transition between elastic and muscular artery behaviour is within the length of the brachial artery, where the site of transition from elastic to muscular wall structure needs to be specified in future studies. |
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Authors:
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N Bjarnegård; A Rydén Ahlgren; B Sonesson; T Länne |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta physiologica Scandinavica Volume: 182 ISSN: 0001-6772 ISO Abbreviation: Acta Physiol. Scand. Publication Date: 2004 Sep |
Date Detail:
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Created Date: 2004-08-26 Completed Date: 2004-12-20 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370362 Medline TA: Acta Physiol Scand Country: England |
Other Details:
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Languages: eng Pagination: 21-7 Citation Subset: IM |
Affiliation:
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Department of Medicine and Care, University of Linköping, Linköping, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aging / physiology Biomechanics Blood Pressure Brachial Artery / anatomy & histology, physiology* Female Forearm / blood supply Heart Rate / physiology Humans Male Physical Stimulation Regional Blood Flow Sympathetic Nervous System / physiology* Vascular Resistance / physiology |
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