Document Detail


The effect of surface treatment using hyaluronic acid and lubricin on the gliding resistance of human extrasynovial tendons in vitro.
MedLine Citation:
PMID:  19556078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate the effects of tendon surface treatment using hyaluronic acid (HA) and lubricin on the gliding resistance of human extrasynovial palmaris longus (PL) tendon in vitro.
METHODS: Thirty-two fresh-frozen cadaver human fingers and 16 ipsilateral PL tendons were used. Each PL tendon was divided into 2 pieces, which were randomly assigned into 4 experimental groups. After the gliding resistance of the normal PL tendon segments were measured, the tendons were treated with either saline, carbodiimide derivatized (cd) gelatin and HA (cd-HA gelatin), cd gelatin with lubricin added (cd gelatin plus lubricin), or cd-HA gelatin plus lubricin. After treatment, tendon gliding resistance was measured during up to 1000 cycles of simulated flexion and extension motion.
RESULTS: The gliding resistance of the PL tendons in the cd-HA gelatin, cd gelatin plus lubricin, and cd-HA gelatin plus lubricin groups was significantly lower than that of the saline-treated control after 1000 cycles. The gliding resistance in these treatment groups decreased within the first 50 cycles and then increased at a much more gradual rate over the 1000 cycles, with the cd-HA gelatin plus lubricin group being most stable.
CONCLUSIONS: The results suggest that tendon surface treatment using HA and lubricin can improve the gliding of human PL tendon in vitro. If validated in vivo, tendon surface treatment has the potential to improve the gliding ability of tendon grafts clinically.
Authors:
Manabu Taguchi; Chunfeng Zhao; Yu-Long Sun; Gregory D Jay; Kai-Nan An; Peter C Amadio
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-06-25
Journal Detail:
Title:  The Journal of hand surgery     Volume:  34     ISSN:  1531-6564     ISO Abbreviation:  J Hand Surg Am     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-24     Completed Date:  2010-01-15     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  7609631     Medline TA:  J Hand Surg Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1276-81     Citation Subset:  IM    
Affiliation:
Orthopedic Biomechanics Laboratory, Division of Orthopedic Research, Mayo Clinic, Rochester, MN 55905, USA.
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MeSH Terms
Descriptor/Qualifier:
Cadaver
Finger Joint
Friction / drug effects*
Glycoproteins / pharmacology*
Humans
Hyaluronic Acid / pharmacology*
Joint Capsule / drug effects*
Range of Motion, Articular
Shear Strength / drug effects
Surface Properties / drug effects
Tendons / drug effects*
Tissue Culture Techniques
Viscosupplements / pharmacology*
Grant Support
ID/Acronym/Agency:
R01 AR044391-08/AR/NIAMS NIH HHS; R01 AR044391-14/AR/NIAMS NIH HHS; R01 AR057745-01/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Glycoproteins; 0/Viscosupplements; 0/lubricin; 9004-61-9/Hyaluronic Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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