Document Detail


The effect of sulconazole on the antigenic composition of two dermatophyte species.
MedLine Citation:
PMID:  1474985     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Trichophyton rubrum and Trichophyton interdigitale have been grown in liquid culture in the presence of sulconazole. The antigenic activity of detergent extracts of intact organisms was analysed following SDS-PAGE and the probing of Western blots with homologous antisera raised in rabbits and with sera from patients with dermatophyte infections. Differences in protein-band patterns were noted; some bands present in control samples were absent in azole-treated samples and vice versa. These differences were reflected in antigenic band patterns, especially among components of approximate molecular weight of 30-40, 50-60 and 92-100 kDa.
Authors:
V M Hearn; M K Moore; J P Latgé; J N Fracchia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mycoses     Volume:  35     ISSN:  0933-7407     ISO Abbreviation:  Mycoses     Publication Date:    1992 May-Jun
Date Detail:
Created Date:  1993-01-29     Completed Date:  1993-01-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8805008     Medline TA:  Mycoses     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  141-5     Citation Subset:  IM    
Affiliation:
Mycological Reference Laboratory, Central Public Health Laboratory, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antifungal Agents / pharmacology*
Antigens, Fungal / analysis*,  drug effects
Detergents
Fungal Proteins / analysis,  drug effects
Glycoproteins / analysis,  drug effects
Humans
Imidazoles / pharmacology*
Rabbits
Trichophyton / drug effects*,  growth & development
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Antigens, Fungal; 0/Detergents; 0/Fungal Proteins; 0/Glycoproteins; 0/Imidazoles; 61318-90-9/sulconazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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